FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3189779043> ?p ?o ?g. }

• W3189779043 endingPage "1038" @default.
• W3189779043 startingPage "1038" @default.
• W3189779043 abstract "The low complexity domain (LCD) sequence has been defined in terms of entropy using a 12 amino acid sliding window along a protein sequence in the study of disease-related genes. The amyotrophic lateral sclerosis (ALS)-related TDP-43 protein sequence with intra-LCD structural information based on cryo-EM data was published recently. An application of entropy and Higuchi fractal dimension calculations was described using the Znf521 and HAR1 sequences. A computational analysis of the intra-LCD sequence entropy and Higuchi fractal dimension values at the amino acid level and at the ATCG nucleotide level were conducted without the sliding window requirement. The computational results were consistent in predicting the intermediate entropy/fractal dimension value produced when two subsequences at two different entropy/fractal dimension values were combined. The computational method without the application of a sliding-window was extended to an analysis of the recently reported virulent genes—Orf6, Nsp6, and Orf7a—in SARS-CoV-2. The relationship between the virulence functionality and entropy values was found to have correlation coefficients between 0.84 and 0.99, using a 5% uncertainty on the cell viability data. The analysis found that the most virulent Orf6 gene sequence had the lowest nucleotide entropy and the highest protein fractal dimension, in line with extreme value theory. The Orf6 codon usage bias in relation to vaccine design was discussed." @default.
• W3189779043 created "2021-08-16" @default.
• W3189779043 creator A5036724513 @default.
• W3189779043 creator A5054579740 @default.
• W3189779043 creator A5059285254 @default.
• W3189779043 creator A5057703161 @default.
• W3189779043 date "2021-08-12" @default.
• W3189779043 modified "2023-09-27" @default.
• W3189779043 title "Entropy and Fractal Dimension Study of the TDP-43 Protein Low Complexity Domain Sequence in ALS Disease Severity and SARS-CoV-2 Gene Sequences in Virulence Variability" @default.
• W3189779043 cites W1966637715 @default.
• W3189779043 cites W1986069605 @default.
• W3189779043 cites W1994233698 @default.
• W3189779043 cites W2007356320 @default.
• W3189779043 cites W2023921790 @default.
• W3189779043 cites W2117614080 @default.
• W3189779043 cites W2144546507 @default.
• W3189779043 cites W2146120203 @default.
• W3189779043 cites W2165101781 @default.
• W3189779043 cites W2911237161 @default.
• W3189779043 cites W2913470513 @default.
• W3189779043 cites W2950448148 @default.
• W3189779043 cites W2951562469 @default.
• W3189779043 cites W2971718802 @default.
• W3189779043 cites W2971747221 @default.
• W3189779043 cites W2990752535 @default.
• W3189779043 cites W2995886801 @default.
• W3189779043 cites W3002679225 @default.
• W3189779043 cites W3081901842 @default.
• W3189779043 cites W3095839623 @default.
• W3189779043 cites W3117154968 @default.
• W3189779043 cites W3127701774 @default.
• W3189779043 cites W3133558561 @default.
• W3189779043 cites W3134906456 @default.
• W3189779043 cites W3136083598 @default.
• W3189779043 cites W3137886193 @default.
• W3189779043 cites W3139390776 @default.
• W3189779043 cites W3160281400 @default.
• W3189779043 doi "https://doi.org/10.3390/e23081038" @default.
• W3189779043 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8393862" @default.
• W3189779043 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34441178" @default.
• W3189779043 hasPublicationYear "2021" @default.
• W3189779043 type Work @default.
• W3189779043 sameAs 3189779043 @default.
• W3189779043 citedByCount "1" @default.
• W3189779043 countsByYear W31897790432023 @default.
• W3189779043 crossrefType "journal-article" @default.
• W3189779043 hasAuthorship W3189779043A5036724513 @default.
• W3189779043 hasAuthorship W3189779043A5054579740 @default.
• W3189779043 hasAuthorship W3189779043A5057703161 @default.
• W3189779043 hasAuthorship W3189779043A5059285254 @default.
• W3189779043 hasBestOaLocation W31897790431 @default.
• W3189779043 hasConcept C102392041 @default.
• W3189779043 hasConcept C104317684 @default.
• W3189779043 hasConcept C106301342 @default.
• W3189779043 hasConcept C110601934 @default.
• W3189779043 hasConcept C111919701 @default.
• W3189779043 hasConcept C121332964 @default.
• W3189779043 hasConcept C134306372 @default.
• W3189779043 hasConcept C26546657 @default.
• W3189779043 hasConcept C2778751112 @default.
• W3189779043 hasConcept C32909587 @default.
• W3189779043 hasConcept C33923547 @default.
• W3189779043 hasConcept C40636538 @default.
• W3189779043 hasConcept C41008148 @default.
• W3189779043 hasConcept C54355233 @default.
• W3189779043 hasConcept C60987743 @default.
• W3189779043 hasConcept C62520636 @default.
• W3189779043 hasConcept C69308434 @default.
• W3189779043 hasConcept C70721500 @default.
• W3189779043 hasConcept C86803240 @default.
• W3189779043 hasConcept C97355855 @default.
• W3189779043 hasConceptScore W3189779043C102392041 @default.
• W3189779043 hasConceptScore W3189779043C104317684 @default.
• W3189779043 hasConceptScore W3189779043C106301342 @default.
• W3189779043 hasConceptScore W3189779043C110601934 @default.
• W3189779043 hasConceptScore W3189779043C111919701 @default.
• W3189779043 hasConceptScore W3189779043C121332964 @default.
• W3189779043 hasConceptScore W3189779043C134306372 @default.
• W3189779043 hasConceptScore W3189779043C26546657 @default.
• W3189779043 hasConceptScore W3189779043C2778751112 @default.
• W3189779043 hasConceptScore W3189779043C32909587 @default.
• W3189779043 hasConceptScore W3189779043C33923547 @default.
• W3189779043 hasConceptScore W3189779043C40636538 @default.
• W3189779043 hasConceptScore W3189779043C41008148 @default.
• W3189779043 hasConceptScore W3189779043C54355233 @default.
• W3189779043 hasConceptScore W3189779043C60987743 @default.
• W3189779043 hasConceptScore W3189779043C62520636 @default.
• W3189779043 hasConceptScore W3189779043C69308434 @default.
• W3189779043 hasConceptScore W3189779043C70721500 @default.
• W3189779043 hasConceptScore W3189779043C86803240 @default.
• W3189779043 hasConceptScore W3189779043C97355855 @default.
• W3189779043 hasIssue "8" @default.
• W3189779043 hasLocation W31897790431 @default.
• W3189779043 hasLocation W31897790432 @default.
• W3189779043 hasLocation W31897790433 @default.
• W3189779043 hasOpenAccess W3189779043 @default.
• W3189779043 hasPrimaryLocation W31897790431 @default.
• W3189779043 hasRelatedWork W2007723793 @default.

• next