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- W3189794980 endingPage "8555" @default.
- W3189794980 startingPage "8555" @default.
- W3189794980 abstract "The current treatment options for type 2 diabetes mellitus do not adequately control the disease in many patients. Consequently, there is a need for new drugs to prevent and treat type 2 diabetes mellitus. Among the new potential pharmacological strategies, activators of peroxisome proliferator-activated receptor (PPAR)β/δ show promise. Remarkably, most of the antidiabetic effects of PPARβ/δ agonists involve AMP-activated protein kinase (AMPK) activation. This review summarizes the recent mechanistic insights into the antidiabetic effects of the PPARβ/δ-AMPK pathway, including the upregulation of glucose uptake, muscle remodeling, enhanced fatty acid oxidation, and autophagy, as well as the inhibition of endoplasmic reticulum stress and inflammation. A better understanding of the mechanisms underlying the effects resulting from the PPARβ/δ-AMPK pathway may provide the basis for the development of new therapies in the prevention and treatment of insulin resistance and type 2 diabetes mellitus." @default.
- W3189794980 created "2021-08-16" @default.
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- W3189794980 creator A5031803983 @default.
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- W3189794980 date "2021-08-09" @default.
- W3189794980 modified "2023-10-13" @default.
- W3189794980 title "The PPARβ/δ-AMPK Connection in the Treatment of Insulin Resistance" @default.
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- W3189794980 doi "https://doi.org/10.3390/ijms22168555" @default.
- W3189794980 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8395240" @default.
- W3189794980 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34445261" @default.
- W3189794980 hasPublicationYear "2021" @default.
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