FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3189799734> ?p ?o ?g. }

• W3189799734 abstract "Primary age-related tauopathy (PART) is a form of Alzheimer-type neurofibrillary degeneration occurring in the absence of amyloid-beta (Aβ) plaques. While PART shares some features with Alzheimer disease (AD), such as progressive accumulation of neurofibrillary tangle pathology in the medial temporal lobe and other brain regions, it does not progress extensively to neocortical regions. Given this restricted pathoanatomical pattern and variable symptomatology, there is a need to reexamine and improve upon how PART is neuropathologically assessed and staged. We performed a retrospective autopsy study in a collection (n = 174) of post-mortem PART brains and used logistic regression to determine the extent to which a set of clinical and neuropathological features predict cognitive impairment. We compared Braak staging, which focuses on hierarchical neuroanatomical progression of AD tau and Aβ pathology, with quantitative assessments of neurofibrillary burden using computer-derived positive pixel counts on digitized whole slide images of sections stained immunohistochemically with antibodies targeting abnormal hyperphosphorylated tau (p-tau) in the entorhinal region and hippocampus. We also assessed other factors affecting cognition, including aging-related tau astrogliopathy (ARTAG) and atrophy. We found no association between Braak stage and cognitive impairment when controlling for age (p = 0.76). In contrast, p-tau burden was significantly correlated with cognitive impairment even when adjusting for age (p = 0.03). The strongest correlate of cognitive impairment was cerebrovascular disease, a well-known risk factor (p < 0.0001), but other features including ARTAG (p = 0.03) and hippocampal atrophy (p = 0.04) were also associated. In contrast, sex, APOE, psychiatric illness, education, argyrophilic grains, and incidental Lewy bodies were not. These findings support the hypothesis that comorbid pathologies contribute to cognitive impairment in subjects with PART. Quantitative approaches beyond Braak staging are critical for advancing our understanding of the extent to which age-related tauopathy changes impact cognitive function." @default.
• W3189799734 created "2021-08-16" @default.
• W3189799734 creator A5000414426 @default.
• W3189799734 creator A5008713279 @default.
• W3189799734 creator A5009533777 @default.
• W3189799734 creator A5020784702 @default.
• W3189799734 creator A5021394368 @default.
• W3189799734 creator A5022636023 @default.
• W3189799734 creator A5024037570 @default.
• W3189799734 creator A5024767343 @default.
• W3189799734 creator A5027135495 @default.
• W3189799734 creator A5032902085 @default.
• W3189799734 creator A5035094092 @default.
• W3189799734 creator A5036454720 @default.
• W3189799734 creator A5037938359 @default.
• W3189799734 creator A5040631126 @default.
• W3189799734 creator A5047032528 @default.
• W3189799734 creator A5054795331 @default.
• W3189799734 creator A5061968243 @default.
• W3189799734 creator A5062747813 @default.
• W3189799734 creator A5063529297 @default.
• W3189799734 creator A5066548665 @default.
• W3189799734 creator A5067638615 @default.
• W3189799734 creator A5068784480 @default.
• W3189799734 creator A5072613176 @default.
• W3189799734 creator A5081784983 @default.
• W3189799734 creator A5087473363 @default.
• W3189799734 date "2021-08-05" @default.
• W3189799734 modified "2023-10-16" @default.
• W3189799734 title "Predictors of cognitive impairment in primary age-related tauopathy: an autopsy study" @default.
• W3189799734 cites W1548235230 @default.
• W3189799734 cites W1769834772 @default.
• W3189799734 cites W1902303720 @default.
• W3189799734 cites W1958554455 @default.
• W3189799734 cites W1966378897 @default.
• W3189799734 cites W1971032265 @default.
• W3189799734 cites W1979068994 @default.
• W3189799734 cites W1992842030 @default.
• W3189799734 cites W1999864873 @default.
• W3189799734 cites W2002896646 @default.
• W3189799734 cites W2031601703 @default.
• W3189799734 cites W2032221178 @default.
• W3189799734 cites W2041976347 @default.
• W3189799734 cites W2044367669 @default.
• W3189799734 cites W2047542833 @default.
• W3189799734 cites W2052742260 @default.
• W3189799734 cites W2054798938 @default.
• W3189799734 cites W2066792703 @default.
• W3189799734 cites W2071031995 @default.
• W3189799734 cites W2075576303 @default.
• W3189799734 cites W2079716752 @default.
• W3189799734 cites W2084453905 @default.
• W3189799734 cites W2105071925 @default.
• W3189799734 cites W2107960095 @default.
• W3189799734 cites W2109618844 @default.
• W3189799734 cites W2111405228 @default.
• W3189799734 cites W2116617730 @default.
• W3189799734 cites W2125985978 @default.
• W3189799734 cites W2128228199 @default.
• W3189799734 cites W2141679195 @default.
• W3189799734 cites W2146729934 @default.
• W3189799734 cites W2170906442 @default.
• W3189799734 cites W2195527239 @default.
• W3189799734 cites W2217184110 @default.
• W3189799734 cites W2334428983 @default.
• W3189799734 cites W2397952616 @default.
• W3189799734 cites W2406403419 @default.
• W3189799734 cites W2529069379 @default.
• W3189799734 cites W2541361002 @default.
• W3189799734 cites W2551564313 @default.
• W3189799734 cites W2584431885 @default.
• W3189799734 cites W2592069554 @default.
• W3189799734 cites W2596999834 @default.
• W3189799734 cites W2600568507 @default.
• W3189799734 cites W2756191472 @default.
• W3189799734 cites W2756959977 @default.
• W3189799734 cites W2798054687 @default.
• W3189799734 cites W2808340672 @default.
• W3189799734 cites W2883434451 @default.
• W3189799734 cites W2898846419 @default.
• W3189799734 cites W2900909585 @default.
• W3189799734 cites W2901725597 @default.
• W3189799734 cites W2905006249 @default.
• W3189799734 cites W2913901142 @default.
• W3189799734 cites W2914510801 @default.
• W3189799734 cites W2914546793 @default.
• W3189799734 cites W2924711286 @default.
• W3189799734 cites W2943828894 @default.
• W3189799734 cites W2996573401 @default.
• W3189799734 cites W2998876182 @default.
• W3189799734 cites W3017188906 @default.
• W3189799734 cites W3042582463 @default.
• W3189799734 cites W3045412576 @default.
• W3189799734 cites W3116816451 @default.
• W3189799734 cites W3160467258 @default.
• W3189799734 doi "https://doi.org/10.1186/s40478-021-01233-3" @default.
• W3189799734 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8340493" @default.
• W3189799734 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34353357" @default.
• W3189799734 hasPublicationYear "2021" @default.
• W3189799734 type Work @default.

• next