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• W3189942097 abstract "Abstract Like humans, weight control in overweight dogs is associated with a longer life expectancy and a healthier life. Dietary supplements are one of the best strategies for controlling obesity and obesity-associated diseases. This study was conducted to assess the potential of black ginseng (BG) and silkworm (SW) as supplements for weight control in diet-induced overweight beagle dogs. To investigate the changes that occur in dogs administered the supplements, different obesity-related parameters, such as body condition score (BCS), blood fatty acid profile, transcriptome, and microbiome, were assessed in high energy diet (HD) and HD with BG + SW supplementation (HDT) groups of test animals. After 12 weeks of BG + SW supplementation, total cholesterol and triglyceride levels were reduced in the HDT group. In the transcriptome analysis, nine genes ( NUGGC , EFR3B , RTP4 , ACAN , HOXC4 , IL17RB , SOX13 , SLC18A2 , and SOX4 ) that are known to be associated with obesity were found to be differentially expressed between the ND (normal diet) and HD groups as well as the HD and HDT groups. Significant changes in some taxa were observed between the HD and ND groups. These data suggest that the BG + SW supplement could be developed as dietary interventions against diet-induced obesity, and obesity-related differential genes could be important candidates in the mechanism of the anti-obesity effects of the BG + SW supplement." @default.
• W3189942097 created "2021-08-16" @default.
• W3189942097 creator A5015137786 @default.
• W3189942097 creator A5023128005 @default.
• W3189942097 creator A5048965180 @default.
• W3189942097 creator A5050194136 @default.
• W3189942097 creator A5071211663 @default.
• W3189942097 creator A5071727338 @default.
• W3189942097 creator A5078539372 @default.
• W3189942097 creator A5089054890 @default.
• W3189942097 date "2021-08-11" @default.
• W3189942097 modified "2023-10-15" @default.
• W3189942097 title "Effect of black ginseng and silkworm supplementation on obesity, the transcriptome, and the gut microbiome of diet-induced overweight dogs" @default.
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