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- W3190054906 abstract "Abstract It has been widely discussed that the topological characteristics of the functional brain network in post-traumatic stress disorder (PTSD) demonstrates impairments, but the topology of structural covariance network has rarely been studied. Based on graph theoretical approaches, we compared the topological organization of structural covariance networks among PTSD, trauma-exposed control (TEC) group and healthy control (HC) group by constructing covariance networks of cortical thickness. Structural magnetic resonance imaging (sMRI) scans and clinical scales were performed in 27 PTSD, 33 TEC and 29 HC subjects. Based on the cortical thickness correlations, morphological network was constructed and analyzed for each group. Pearson correlation coefficients were computed to explore the relationship of brain network measurements with clinical scales. PTSD and HC subjects did not differ at the global level. Significantly increased clustering coefficient ( p = .014) and local efficiency ( p = .031) were observed in PTSD group compared with TEC subjects. At the nodal level, PTSD showed extensive increased nodal centralities in comparison to the other two groups ( p < .05, uncorrected for false-discovery rate). The structural brain network topological characteristics found in this study suggest that PTSD manifests differently compared to TEC group from pathophysiological perspective. Greater network separation and increased nodal centrality in PTSD patients may be concerning emotional disorders." @default.
- W3190054906 created "2021-08-16" @default.
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- W3190054906 date "2021-08-10" @default.
- W3190054906 modified "2023-09-24" @default.
- W3190054906 title "Study on the Changes of Structural Covariance Network in Post-traumatic Stress Disorder" @default.
- W3190054906 doi "https://doi.org/10.21203/rs.3.rs-779634/v1" @default.
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