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• W3190062375 abstract "The reference Cunningham et al. is ineligible to our eligibility criteria. We used this reference in three forest plots in our original paper. The first one is in subgroup analysis in Figure 3 (see colorectal cancer), the second one is in Figure 4 (see non-platinum-based regimen) and the last one is in Supporting Information Figure S1 (see colorectal cancer). Here, we recalculate the pooled results after omitting this reference. The new RR in Figure 3 is 1.13 (95% CI 1.03–1.24), in Figure 4 is 1.11 (95% CI 1.00–1.22) (see updated Fig. 1), and in Supporting Information Figure S1 is 1.68 (95% CI 1.09–2.58) (updated Fig. 2). However, all of them are in line with our previous results. Non-platinum-based regimen without Cunningham. [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.] Anemia AEs in colorectal cancer without Cunningham. [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.] The reference Rosell et al., which reports the data regarding the Leukopenia and Neutropenia AEs, had been missed in subgroup analysis in Figure 3 (see NSCLC) in our paper. Here we add this reference and respectively recalculate the pooled results using the data provided by Sterrantino and coworkers. The RR for Neutropenia AEs is 1.09 (95% CI 1.01–1.18) (updated Fig. 3) and that of Leukopenia AEs is 0.91 (95% CI 0.80–1.03), pheterogeneity = 0.0000, I2 = 96.6% (updated Fig. 4). Given that the pheterogeneity is high, we explore the heterogeneity among included four studies (Lynch et al.; Piker et al.; Rosell et al.; Philip et al.). Exclusion of study by Philip et al. yields a RR of 1.36 (95% CI 1.17–1.57) with no heterogeneity among the remaining studies (pheterogeneity = 0.885, I2 = 0.0%), suggesting that study by Philip et al. contributed much to the heterogeneity (updated Fig. 5). Therefore, our present meta-analysis showed that cetuximab was associated with increased slight risk of ≥Grade 3 Leukopenia and Neutropenia AEs in NSCLC. Neutropenia AEs in NSCLC. [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.] Leukopenia AEs in NSCLC. [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.] Leukopenia AEs in NSCLC without Philip. [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.] Yours sincerely, Ran Cui, Li Chu, Zhu-Qing Liu, Yuan-Yuan Xiao, Xiao-Li Zhu, Yi-Jing Chen and Qing Xu" @default.
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• W3190062375 date "2016-02-21" @default.
• W3190062375 modified "2023-10-14" @default.
• W3190062375 title "Hematologic toxicity assessment in solid tumor patients treated with cetuximab: A pooled analysis of 18 randomized controlled trials" @default.
• W3190062375 doi "https://doi.org/10.1002/ijc.30004" @default.
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