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• W3190122135 endingPage "8218" @default.
• W3190122135 startingPage "8218" @default.
• W3190122135 abstract "Febrile seizures (FSs) in early life are significant risk factors of neurological disorders and cognitive impairment in later life. However, existing data about the impact of FSs on the developing brain are conflicting. We aimed to investigate morphological and functional changes in the hippocampus of young rats exposed to hyperthermia-induced seizures at postnatal day 10. We found that FSs led to a slight morphological disturbance. The cell numbers decreased by 10% in the CA1 and hilus but did not reduce in the CA3 or dentate gyrus areas. In contrast, functional impairments were robust. Long-term potentiation (LTP) in CA3-CA1 synapses was strongly reduced, which we attribute to the insufficient activity of N-methyl-D-aspartate receptors (NMDARs). Using whole-cell recordings, we found higher desensitization of NMDAR currents in the FS group. Since the desensitization of NMDARs depends on subunit composition, we analyzed NMDAR current decays and gene expression of subunits, which revealed no differences between control and FS rats. We suggest that an increased desensitization is due to insufficient activation of the glycine site of NMDARs, as the application of D-serine, the glycine site agonist, allows the restoration of LTP to a control value. Our results reveal a new molecular mechanism of FS impact on the developing brain." @default.
• W3190122135 created "2021-08-16" @default.
• W3190122135 creator A5054294231 @default.
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• W3190122135 creator A5072434337 @default.
• W3190122135 date "2021-07-30" @default.
• W3190122135 modified "2023-10-18" @default.
• W3190122135 title "Early Life Febrile Seizures Impair Hippocampal Synaptic Plasticity in Young Rats" @default.
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• W3190122135 cites W1498439263 @default.
• W3190122135 cites W1519160881 @default.
• W3190122135 cites W1722159370 @default.
• W3190122135 cites W1880320779 @default.
• W3190122135 cites W1923778490 @default.
• W3190122135 cites W1953681520 @default.
• W3190122135 cites W1965435872 @default.
• W3190122135 cites W1974398884 @default.
• W3190122135 cites W1976639286 @default.
• W3190122135 cites W1990960994 @default.
• W3190122135 cites W1993366021 @default.
• W3190122135 cites W1995536650 @default.
• W3190122135 cites W2006617150 @default.
• W3190122135 cites W2013632767 @default.
• W3190122135 cites W2014224464 @default.
• W3190122135 cites W2015778322 @default.
• W3190122135 cites W2018481821 @default.
• W3190122135 cites W2019179420 @default.
• W3190122135 cites W2024921008 @default.
• W3190122135 cites W2025514880 @default.
• W3190122135 cites W2028603811 @default.
• W3190122135 cites W2036439010 @default.
• W3190122135 cites W2044315590 @default.
• W3190122135 cites W2045818277 @default.
• W3190122135 cites W2048088057 @default.
• W3190122135 cites W2049511526 @default.
• W3190122135 cites W2050295653 @default.
• W3190122135 cites W2063439606 @default.
• W3190122135 cites W2067074086 @default.
• W3190122135 cites W2071908149 @default.
• W3190122135 cites W2072621033 @default.
• W3190122135 cites W2081874117 @default.
• W3190122135 cites W2082752208 @default.
• W3190122135 cites W2083337256 @default.
• W3190122135 cites W2086279118 @default.
• W3190122135 cites W2086957009 @default.
• W3190122135 cites W2088126601 @default.
• W3190122135 cites W2089699179 @default.
• W3190122135 cites W2090468125 @default.
• W3190122135 cites W2106645298 @default.
• W3190122135 cites W2107277218 @default.
• W3190122135 cites W2108314612 @default.
• W3190122135 cites W2109909801 @default.
• W3190122135 cites W2112927743 @default.
• W3190122135 cites W2114362693 @default.
• W3190122135 cites W2135251933 @default.
• W3190122135 cites W2136042143 @default.
• W3190122135 cites W2141114982 @default.
• W3190122135 cites W2141168272 @default.
• W3190122135 cites W2148128786 @default.
• W3190122135 cites W2161964605 @default.
• W3190122135 cites W2163922059 @default.
• W3190122135 cites W2164871875 @default.
• W3190122135 cites W2166602830 @default.
• W3190122135 cites W2208766333 @default.
• W3190122135 cites W2291858553 @default.
• W3190122135 cites W2339133917 @default.
• W3190122135 cites W2412111181 @default.
• W3190122135 cites W2513828441 @default.
• W3190122135 cites W2514362844 @default.
• W3190122135 cites W2558750425 @default.
• W3190122135 cites W2567450089 @default.
• W3190122135 cites W2747735418 @default.
• W3190122135 cites W2750775516 @default.
• W3190122135 cites W2791167513 @default.
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• W3190122135 doi "https://doi.org/10.3390/ijms22158218" @default.
• W3190122135 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8347828" @default.
• W3190122135 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34360983" @default.
• W3190122135 hasPublicationYear "2021" @default.
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