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- W3190127007 abstract "This paper presents the thermodynamic analysis of solubility of gatifloxacin in the N,N-Dimethylformamide (DMF) + methanol (MeOH) cosolvent system at 10 temperatures. From the solubility data, the thermodynamic functions of solution, mixing, and transfers are calculated and analyzed using the Perlovich graphical method. On the other hand, an enthalpy-entropy compensation analysis is performed and the preferential solvation parameters are calculated using the inverse Kirkwood-Buff integral (IKBI) method. The result of the performed calculations indicates that the gatifloxacin solution process is endothermic with entropic favor, where the addition of DMF has a positive cosolvent effect in all cases. Regarding preferential solvation, the results are not entirely conclusive, since in all cases the values of the preferential solvation parameter are less than 0.01, so that, negligible preferential solvation takes place." @default.
- W3190127007 created "2021-08-16" @default.
- W3190127007 creator A5008412208 @default.
- W3190127007 date "2020-01-01" @default.
- W3190127007 modified "2023-09-27" @default.
- W3190127007 title "Thermodynamic analysis and preferential solvation of gatifloxacin in DMF + methanol cosolvent mixtures" @default.
- W3190127007 doi "https://doi.org/10.2139/ssrn.3874287" @default.
- W3190127007 hasPublicationYear "2020" @default.
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