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- W3190251030 abstract "Premature ovarian insufficiency (POI) is a complex endocrine disease that severely affects the physiological and reproductive functions of females. The current conventional clinical treatment methods for POI are characterized by several side effects, and most do not effectively restore the physiological functions of the ovaries. Transplantation of mesenchymal stem cells (MSCs) is a promising regenerative medicine approach, which has received significant attention in the management of POI with high efficacy. Associated pre-clinical and clinical trials are also proceeding orderly. However, the therapeutic mechanisms underlying the MSCs-based treatment are complex and have not been fully elucidated. In brief, proliferation, apoptosis, immunization, autophagy, oxidative stress, and fibrosis of ovarian cells are modulated through paracrine effects after migration of MSCs to the injured ovary. This review summarizes therapeutic mechanisms of MSCs-based treatments in POI and explores their therapeutic potential in clinical practice. Therefore, this review will provide a theoretical basis for further research and clinical application of MSCs in POI." @default.
- W3190251030 created "2021-08-16" @default.
- W3190251030 creator A5014942240 @default.
- W3190251030 creator A5033470329 @default.
- W3190251030 creator A5058401675 @default.
- W3190251030 creator A5078730997 @default.
- W3190251030 creator A5079200691 @default.
- W3190251030 date "2021-08-03" @default.
- W3190251030 modified "2023-10-18" @default.
- W3190251030 title "Mesenchymal Stem Cells in Premature Ovarian Insufficiency: Mechanisms and Prospects" @default.
- W3190251030 cites W1534731743 @default.
- W3190251030 cites W1580771990 @default.
- W3190251030 cites W1960997296 @default.
- W3190251030 cites W1967038189 @default.
- W3190251030 cites W1968452866 @default.
- W3190251030 cites W1979043688 @default.
- W3190251030 cites W1981743114 @default.
- W3190251030 cites W1992186496 @default.
- W3190251030 cites W2000115558 @default.
- W3190251030 cites W2004435141 @default.
- W3190251030 cites W2005381457 @default.
- W3190251030 cites W2012549032 @default.
- W3190251030 cites W2015215491 @default.
- W3190251030 cites W2020902818 @default.
- W3190251030 cites W2022346732 @default.
- W3190251030 cites W2022955538 @default.
- W3190251030 cites W2025371271 @default.
- W3190251030 cites W2027805356 @default.
- W3190251030 cites W2035065708 @default.
- W3190251030 cites W2038485256 @default.
- W3190251030 cites W2039031583 @default.
- W3190251030 cites W2040394154 @default.
- W3190251030 cites W2042060958 @default.
- W3190251030 cites W2043264689 @default.
- W3190251030 cites W2046663172 @default.
- W3190251030 cites W2047202223 @default.
- W3190251030 cites W2047647041 @default.
- W3190251030 cites W2048270850 @default.
- W3190251030 cites W2049939829 @default.
- W3190251030 cites W2054238236 @default.
- W3190251030 cites W2054274983 @default.
- W3190251030 cites W2055313665 @default.
- W3190251030 cites W2060112923 @default.
- W3190251030 cites W2062948400 @default.
- W3190251030 cites W2079355772 @default.
- W3190251030 cites W2079691345 @default.
- W3190251030 cites W2081089662 @default.
- W3190251030 cites W2081100505 @default.
- W3190251030 cites W2092984666 @default.
- W3190251030 cites W2102532426 @default.
- W3190251030 cites W2104085328 @default.
- W3190251030 cites W2105557571 @default.
- W3190251030 cites W2116869982 @default.
- W3190251030 cites W2119533233 @default.
- W3190251030 cites W2123771262 @default.
- W3190251030 cites W2130239194 @default.
- W3190251030 cites W2134128777 @default.
- W3190251030 cites W2135416519 @default.
- W3190251030 cites W2135743018 @default.
- W3190251030 cites W2136865861 @default.
- W3190251030 cites W2138818297 @default.
- W3190251030 cites W2139921809 @default.
- W3190251030 cites W2143599194 @default.
- W3190251030 cites W2144268541 @default.
- W3190251030 cites W2145265436 @default.
- W3190251030 cites W2149487482 @default.
- W3190251030 cites W2149502249 @default.
- W3190251030 cites W2153949260 @default.
- W3190251030 cites W2154776022 @default.
- W3190251030 cites W2155044423 @default.
- W3190251030 cites W2155688961 @default.
- W3190251030 cites W2156128416 @default.
- W3190251030 cites W2159358845 @default.
- W3190251030 cites W2159401023 @default.
- W3190251030 cites W2159999899 @default.
- W3190251030 cites W2171466896 @default.
- W3190251030 cites W2280633261 @default.
- W3190251030 cites W2301597926 @default.
- W3190251030 cites W2301922197 @default.
- W3190251030 cites W2308102273 @default.
- W3190251030 cites W2309700868 @default.
- W3190251030 cites W2341026696 @default.
- W3190251030 cites W2341518345 @default.
- W3190251030 cites W2381646039 @default.
- W3190251030 cites W2478193138 @default.
- W3190251030 cites W2505550239 @default.
- W3190251030 cites W2511760972 @default.
- W3190251030 cites W2512166460 @default.
- W3190251030 cites W2512316953 @default.
- W3190251030 cites W2559178581 @default.
- W3190251030 cites W2580328223 @default.
- W3190251030 cites W2588739742 @default.
- W3190251030 cites W2593036422 @default.
- W3190251030 cites W2742041626 @default.
- W3190251030 cites W2748461048 @default.
- W3190251030 cites W2759674016 @default.
- W3190251030 cites W2765760842 @default.
- W3190251030 cites W2765963789 @default.
- W3190251030 cites W2769122638 @default.
- W3190251030 cites W2779317704 @default.