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• W3190251338 abstract "Abstract Neural circuits can produce similar activity patterns from vastly different combinations of channel and synaptic conductances. These conductances are tuned for specific activity patterns but might also reflect additional constraints, such as metabolic cost or robustness to perturbations. How do such constraints influence the range of permissible conductances? Here, we investigate how metabolic cost affects the parameters of neural circuits with similar activity in a model of the pyloric network of the crab Cancer borealis . We use a novel machine learning method to identify a range of network models that can generate activity patterns matching experimental data, and find that neural circuits can consume largely different amounts of energy despite similar circuit activity. Furthermore, a reduced but still significant range of circuit parameters gives rise to energy-efficient circuits. We then examine the space of parameters of energy-efficient circuits and identify potential tuning strategies for low metabolic cost. Finally, we investigate the interaction between metabolic cost and temperature robustness. We show that metabolic cost can vary across temperatures, but that robustness to temperature changes does not necessarily incur an increased metabolic cost. Our analyses show that, despite metabolic efficiency and temperature robustness constraining circuit parameters, neural systems can generate functional, efficient, and robust network activity with widely disparate sets of conductances." @default.
• W3190251338 created "2021-08-16" @default.
• W3190251338 creator A5047668885 @default.
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• W3190251338 date "2021-08-02" @default.
• W3190251338 modified "2023-10-02" @default.
• W3190251338 title "Energy efficient network activity from disparate circuit parameters" @default.
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• W3190251338 doi "https://doi.org/10.1101/2021.07.30.454484" @default.
• W3190251338 hasPublicationYear "2021" @default.
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