Matches in SemOpenAlex for { <https://semopenalex.org/work/W3190283531> ?p ?o ?g. }
- W3190283531 abstract "Abstract The apical domain of epithelial cells can acquire a diverse array of morphologies and functions, which is critical for the function of epithelial tissues. The Crumbs proteins are evolutionary conserved transmembrane proteins with essential roles in promoting apical domain formation in epithelial cells. The short intracellular tail of Crumbs proteins interacts with a variety of proteins, including the scaffolding protein Pals1 (protein associated with LIN7, Stardust in Drosophila ). Pals1 in turn binds to a second scaffolding protein termed PATJ (Pals1-associated tight junction protein), to form the core Crumbs/Pals1/PATJ Crumbs complex. While essential roles in epithelial organization have been shown for Crumbs proteins in Drosophila and mammalian systems, the three Caenorhabditis elegans crumbs genes are dispensable for epithelial polarization and animal development. Moreover, the presence and functioning of orthologs of Pals1 and PATJ has not been investigated. Here, we identify MAGU-2 and MPZ-1 as the C. elegans orthologs of Pals1 and PATJ, respectively. We show that MAGU-2 interacts with all three Crumbs proteins as well as MPZ-1, and localizes to the apical membrane domain in a Crumbs-dependent fashion. Similar to crumbs mutants, a magu-2 null mutant shows no developmental or epithelial polarity defects. Finally, we show that overexpression of the Crumbs proteins EAT-20 or CRB-3 in the C. elegans intestine can lead to apical membrane expansion. Our results shed light into the composition of the C. elegans Crumbs complex and indicate that the role of Crumbs proteins in promoting apical domain formation is conserved." @default.
- W3190283531 created "2021-08-16" @default.
- W3190283531 creator A5009413618 @default.
- W3190283531 creator A5011462995 @default.
- W3190283531 creator A5020578467 @default.
- W3190283531 creator A5038780928 @default.
- W3190283531 creator A5048037808 @default.
- W3190283531 creator A5052601529 @default.
- W3190283531 creator A5055663089 @default.
- W3190283531 creator A5076029930 @default.
- W3190283531 date "2021-08-10" @default.
- W3190283531 modified "2023-09-26" @default.
- W3190283531 title "Characterization of the composition and functioning of the Crumbs complex in C. elegans" @default.
- W3190283531 cites W107411923 @default.
- W3190283531 cites W1966032423 @default.
- W3190283531 cites W1968628345 @default.
- W3190283531 cites W1984121303 @default.
- W3190283531 cites W1984768151 @default.
- W3190283531 cites W1994755074 @default.
- W3190283531 cites W2006249044 @default.
- W3190283531 cites W2012569825 @default.
- W3190283531 cites W2015207072 @default.
- W3190283531 cites W2029530650 @default.
- W3190283531 cites W2048529602 @default.
- W3190283531 cites W2052254968 @default.
- W3190283531 cites W2072846146 @default.
- W3190283531 cites W2074066126 @default.
- W3190283531 cites W2077159019 @default.
- W3190283531 cites W2077970848 @default.
- W3190283531 cites W2078283443 @default.
- W3190283531 cites W2079210215 @default.
- W3190283531 cites W2083609148 @default.
- W3190283531 cites W2099228538 @default.
- W3190283531 cites W2099626566 @default.
- W3190283531 cites W2102978407 @default.
- W3190283531 cites W2107663397 @default.
- W3190283531 cites W2117876140 @default.
- W3190283531 cites W2118971688 @default.
- W3190283531 cites W2122062715 @default.
- W3190283531 cites W2122356356 @default.
- W3190283531 cites W2127322768 @default.
- W3190283531 cites W2127681818 @default.
- W3190283531 cites W2130786065 @default.
- W3190283531 cites W2132654115 @default.
- W3190283531 cites W2133702185 @default.
- W3190283531 cites W2133862855 @default.
- W3190283531 cites W2139168014 @default.
- W3190283531 cites W2140341433 @default.
- W3190283531 cites W2145586371 @default.
- W3190283531 cites W2158714788 @default.
- W3190283531 cites W2165324125 @default.
- W3190283531 cites W2171747124 @default.
- W3190283531 cites W2517519427 @default.
- W3190283531 cites W2607153951 @default.
- W3190283531 cites W2758927587 @default.
- W3190283531 cites W2799242296 @default.
- W3190283531 cites W3112376646 @default.
- W3190283531 cites W3156458251 @default.
- W3190283531 cites W4250170407 @default.
- W3190283531 doi "https://doi.org/10.1101/2021.08.10.455623" @default.
- W3190283531 hasPublicationYear "2021" @default.
- W3190283531 type Work @default.
- W3190283531 sameAs 3190283531 @default.
- W3190283531 citedByCount "0" @default.
- W3190283531 crossrefType "posted-content" @default.
- W3190283531 hasAuthorship W3190283531A5009413618 @default.
- W3190283531 hasAuthorship W3190283531A5011462995 @default.
- W3190283531 hasAuthorship W3190283531A5020578467 @default.
- W3190283531 hasAuthorship W3190283531A5038780928 @default.
- W3190283531 hasAuthorship W3190283531A5048037808 @default.
- W3190283531 hasAuthorship W3190283531A5052601529 @default.
- W3190283531 hasAuthorship W3190283531A5055663089 @default.
- W3190283531 hasAuthorship W3190283531A5076029930 @default.
- W3190283531 hasBestOaLocation W31902835311 @default.
- W3190283531 hasConcept C104317684 @default.
- W3190283531 hasConcept C118892022 @default.
- W3190283531 hasConcept C143065580 @default.
- W3190283531 hasConcept C144292202 @default.
- W3190283531 hasConcept C144647389 @default.
- W3190283531 hasConcept C1491633281 @default.
- W3190283531 hasConcept C154428179 @default.
- W3190283531 hasConcept C170493617 @default.
- W3190283531 hasConcept C177779419 @default.
- W3190283531 hasConcept C24530287 @default.
- W3190283531 hasConcept C2778944004 @default.
- W3190283531 hasConcept C3018436504 @default.
- W3190283531 hasConcept C39587587 @default.
- W3190283531 hasConcept C41625074 @default.
- W3190283531 hasConcept C49353375 @default.
- W3190283531 hasConcept C529295009 @default.
- W3190283531 hasConcept C54355233 @default.
- W3190283531 hasConcept C86803240 @default.
- W3190283531 hasConcept C95444343 @default.
- W3190283531 hasConceptScore W3190283531C104317684 @default.
- W3190283531 hasConceptScore W3190283531C118892022 @default.
- W3190283531 hasConceptScore W3190283531C143065580 @default.
- W3190283531 hasConceptScore W3190283531C144292202 @default.
- W3190283531 hasConceptScore W3190283531C144647389 @default.
- W3190283531 hasConceptScore W3190283531C1491633281 @default.
- W3190283531 hasConceptScore W3190283531C154428179 @default.