Matches in SemOpenAlex for { <https://semopenalex.org/work/W3190300008> ?p ?o ?g. }
- W3190300008 endingPage "107999" @default.
- W3190300008 startingPage "107999" @default.
- W3190300008 abstract "Bioactive peptides derived from food proteins are becoming increasingly popular due to the growing awareness of their health-promoting properties. The structure and mechanism of anti-cancer action of pentapeptide Glu-Gln-Arg-Pro-Arg (EQRPR) derived from a rice bran protein are not known. Theoretical and experimental methods were employed to fill this gap. The conformation analysis of the EQRPR pentapeptide was performed first and the obtained lowest energy conformer was optimized. The experimental structural data obtained by FTIR and CD spectroscopies agree well with the theoretical results. d-isomer introduced one-by-one to each position and all D-isomers of the peptide were also examined for its possible anti-proteolytic and activity enhancement properties. The molecular docking revealed avid binding of the pentapeptide to the integrins α5β1 and αIIbβ3, with Kd values of 90 nM and 180 nM, respectively. Moreover, the EQRPR and its D-isomers showed strong binding affinities to apo- and holo-forms of Mpro, spike glycoprotein, ACE2, and dACE2. The predicted results indicate that the pentapeptide may significantly inhibit SARS-CoV-2 infection. Thus, the peptide has the potential to be the leading molecule in the drug discovery process as having multifunctional with diverse biological activities." @default.
- W3190300008 created "2021-08-16" @default.
- W3190300008 creator A5000883207 @default.
- W3190300008 creator A5000908491 @default.
- W3190300008 creator A5004703737 @default.
- W3190300008 creator A5020743690 @default.
- W3190300008 creator A5022170330 @default.
- W3190300008 creator A5058499507 @default.
- W3190300008 creator A5070362492 @default.
- W3190300008 creator A5079118403 @default.
- W3190300008 creator A5080515579 @default.
- W3190300008 creator A5086882823 @default.
- W3190300008 date "2021-11-01" @default.
- W3190300008 modified "2023-10-18" @default.
- W3190300008 title "Evaluation of anti-cancer and anti-covid-19 properties of cationic pentapeptide Glu-Gln-Arg-Pro-Arg, from rice bran protein and its d-isomer analogs through molecular docking simulations" @default.
- W3190300008 cites W1493920337 @default.
- W3190300008 cites W1546896179 @default.
- W3190300008 cites W1965284669 @default.
- W3190300008 cites W1970529519 @default.
- W3190300008 cites W1970736249 @default.
- W3190300008 cites W1974783049 @default.
- W3190300008 cites W1978000773 @default.
- W3190300008 cites W1989270637 @default.
- W3190300008 cites W1992045220 @default.
- W3190300008 cites W2001699369 @default.
- W3190300008 cites W2005020315 @default.
- W3190300008 cites W2007969974 @default.
- W3190300008 cites W2013937972 @default.
- W3190300008 cites W2014858249 @default.
- W3190300008 cites W2020473936 @default.
- W3190300008 cites W2025031844 @default.
- W3190300008 cites W2026727321 @default.
- W3190300008 cites W2027727936 @default.
- W3190300008 cites W2043995349 @default.
- W3190300008 cites W2057609017 @default.
- W3190300008 cites W2068275014 @default.
- W3190300008 cites W2071758457 @default.
- W3190300008 cites W2075220870 @default.
- W3190300008 cites W2100621506 @default.
- W3190300008 cites W2104771513 @default.
- W3190300008 cites W2107735396 @default.
- W3190300008 cites W2114286636 @default.
- W3190300008 cites W2118594384 @default.
- W3190300008 cites W2120203321 @default.
- W3190300008 cites W2122199548 @default.
- W3190300008 cites W2126080824 @default.
- W3190300008 cites W2140260269 @default.
- W3190300008 cites W2149811610 @default.
- W3190300008 cites W2157937554 @default.
- W3190300008 cites W2165319492 @default.
- W3190300008 cites W2167705901 @default.
- W3190300008 cites W2279021686 @default.
- W3190300008 cites W2345719659 @default.
- W3190300008 cites W2346499202 @default.
- W3190300008 cites W2347697584 @default.
- W3190300008 cites W2400204193 @default.
- W3190300008 cites W2750074602 @default.
- W3190300008 cites W2797067318 @default.
- W3190300008 cites W2799381897 @default.
- W3190300008 cites W2801697388 @default.
- W3190300008 cites W2888438491 @default.
- W3190300008 cites W2896914402 @default.
- W3190300008 cites W2910569898 @default.
- W3190300008 cites W2950277538 @default.
- W3190300008 cites W2993786642 @default.
- W3190300008 cites W2999112124 @default.
- W3190300008 cites W3009335299 @default.
- W3190300008 cites W3011211676 @default.
- W3190300008 cites W3014067025 @default.
- W3190300008 cites W3014310029 @default.
- W3190300008 cites W3015599845 @default.
- W3190300008 cites W3015608194 @default.
- W3190300008 cites W3041538267 @default.
- W3190300008 cites W3044216590 @default.
- W3190300008 cites W3091122434 @default.
- W3190300008 cites W3091770492 @default.
- W3190300008 cites W3093094957 @default.
- W3190300008 doi "https://doi.org/10.1016/j.jmgm.2021.107999" @default.
- W3190300008 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8325105" @default.
- W3190300008 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34352727" @default.
- W3190300008 hasPublicationYear "2021" @default.
- W3190300008 type Work @default.
- W3190300008 sameAs 3190300008 @default.
- W3190300008 citedByCount "8" @default.
- W3190300008 countsByYear W31903000082022 @default.
- W3190300008 countsByYear W31903000082023 @default.
- W3190300008 crossrefType "journal-article" @default.
- W3190300008 hasAuthorship W3190300008A5000883207 @default.
- W3190300008 hasAuthorship W3190300008A5000908491 @default.
- W3190300008 hasAuthorship W3190300008A5004703737 @default.
- W3190300008 hasAuthorship W3190300008A5020743690 @default.
- W3190300008 hasAuthorship W3190300008A5022170330 @default.
- W3190300008 hasAuthorship W3190300008A5058499507 @default.
- W3190300008 hasAuthorship W3190300008A5070362492 @default.
- W3190300008 hasAuthorship W3190300008A5079118403 @default.
- W3190300008 hasAuthorship W3190300008A5080515579 @default.
- W3190300008 hasAuthorship W3190300008A5086882823 @default.
- W3190300008 hasBestOaLocation W31903000081 @default.