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• W3190306225 abstract "<h3>Importance</h3> Limited evidence suggests exercise reduces blood pressure (BP) in individuals with resistant hypertension, a clinical population with low responsiveness to drug therapy. <h3>Objective</h3> To determine whether an aerobic exercise training intervention reduces ambulatory BP among patients with resistant hypertension. <h3>Design, Settings, and Participants</h3> The Exercise Training in the Treatment of Resistant Hypertension (EnRicH) trial is a prospective, 2-center, single-blinded randomized clinical trial performed at 2 hospital centers in Portugal from March 2017 to December 2019. A total of 60 patients with a diagnosis of resistant hypertension aged 40 to 75 years were prospectively enrolled and observed at the hospitals’ hypertension outpatient clinic. <h3>Interventions</h3> Patients were randomly assigned in a 1:1 ratio to a 12-week moderate-intensity aerobic exercise training program (exercise group) or a usual care control group. The exercise group performed three 40-minute supervised sessions per week in addition to usual care. <h3>Main Outcomes and Measures</h3> The powered primary efficacy measure was 24-hour ambulatory systolic BP change from baseline. Secondary outcomes included daytime and nighttime ambulatory BP, office BP, and cardiorespiratory fitness. <h3>Results</h3> A total of 53 patients completed the study, including 26 in the exercise group and 27 in the control group. Of these, 24 (45%) were women, and the mean (SD) age was 60.1 (8.7) years. Compared with the control group, among those in the exercise group, 24-hour ambulatory systolic BP was reduced by 7.1 mm Hg (95% CI, −12.8 to −1.4;<i>P</i> = .02). Additionally, 24-hour ambulatory diastolic BP (−5.1 mm Hg; 95% CI, −7.9 to −2.3;<i>P</i> = .001), daytime systolic BP (−8.4 mm Hg; 95% CI, −14.3 to −2.5;<i>P</i> = .006), and daytime diastolic BP (−5.7 mm Hg; 95% CI, −9.0 to −2.4;<i>P</i> = .001) were reduced in the exercise group compared with the control group. Office systolic BP (−10.0 mm Hg; 95% CI, −17.6 to −2.5;<i>P</i> = .01) and cardiorespiratory fitness (5.05 mL/kg per minute of oxygen consumption; 95% CI, 3.5 to 6.6;<i>P</i> < .001) also improved in the exercise group compared with the control group. <h3>Conclusions and Relevance</h3> A 12-week aerobic exercise program reduced 24-hour and daytime ambulatory BP as well as office systolic BP in patients with resistant hypertension. These findings provide clinicians with evidence to embrace moderate-intensity aerobic exercise as a standard coadjutant therapy targeting this patient population. <h3>Trial Registration</h3> ClinicalTrials.gov Identifier:NCT03090529" @default.
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• W3190306225 date "2021-11-01" @default.
• W3190306225 modified "2023-10-16" @default.
• W3190306225 title "Effect of Exercise Training on Ambulatory Blood Pressure Among Patients With Resistant Hypertension" @default.
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• W3190306225 doi "https://doi.org/10.1001/jamacardio.2021.2735" @default.
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