Matches in SemOpenAlex for { <https://semopenalex.org/work/W3190363003> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W3190363003 endingPage "11" @default.
- W3190363003 startingPage "1" @default.
- W3190363003 abstract "The aim and objective of this study is to investigate the hypoglycemic, hepatoprotective, hypolipidemic and antioxidant potentials of the methanolic extract of Aristolochia ringens leaf (MLAR) in STZ-induced diabetic wistar rats. The airdried and powdered leaf of the plant (Aristolochia ringens) was extracted by cold maceration and concentrated. In vitro analysis was carried out by screening the extract for phytochemical constituents and antioxidant activities using different models. In vivo analysis was also carried out by randomly dividing forty eight (48) male wistar rats (140-170 g) into eight groups of six (6) rats each. Group 1 served as control; group 2 received STZ (60 mg/kg wt i.p); groups 3 to 8 served as the treatment group. The animals were sacrificed without anesthesia after 30 days and their blood were collected for biochemical investigation. The in vitro results showed that MLAR possesses good antioxidant potential when compared with the standard and it is also known to contain a number of phytochemicals. Also, the administration of STZ caused significant (p<0.05) elevation of the serum level of glucose, ALT AST, GGT, ALP, total cholesterol, LDL, TRIGS, MDA, NO and MPO activity by 100%, 47%, 38%, 32%, 51%, 29%, 34%, 41%, 51%, 29%, 54% and 59% respectively and significant reduction in HDL, Catalase, GPx, GSH, SOD, GST and plasma insulin by 34%, 34%, 61%, 46%, 66%, 55% and 52% respectively, but supplementation with MLAR brought all these parameters close to normal. In conclusion, Aristolochia ringens may be used as a prophylactic and an alternative medicine in the treatment of diabetes mellitus as it was established in this study that it possesses antioxidant, antiinflammatory, hypolipidemic and hypoglycemic effects which may be due to the presence of phytochemicals in it." @default.
- W3190363003 created "2021-08-16" @default.
- W3190363003 creator A5002690670 @default.
- W3190363003 creator A5018670678 @default.
- W3190363003 creator A5023372282 @default.
- W3190363003 creator A5024367565 @default.
- W3190363003 creator A5072308868 @default.
- W3190363003 creator A5074619861 @default.
- W3190363003 date "2021-01-01" @default.
- W3190363003 modified "2023-09-23" @default.
- W3190363003 title "Anti-Diabetic Effect of Methanolic Extract of Aristolochia ringensLeaf" @default.
- W3190363003 doi "https://doi.org/10.35248/2161-1009.21.10.397" @default.
- W3190363003 hasPublicationYear "2021" @default.
- W3190363003 type Work @default.
- W3190363003 sameAs 3190363003 @default.
- W3190363003 citedByCount "0" @default.
- W3190363003 crossrefType "journal-article" @default.
- W3190363003 hasAuthorship W3190363003A5002690670 @default.
- W3190363003 hasAuthorship W3190363003A5018670678 @default.
- W3190363003 hasAuthorship W3190363003A5023372282 @default.
- W3190363003 hasAuthorship W3190363003A5024367565 @default.
- W3190363003 hasAuthorship W3190363003A5072308868 @default.
- W3190363003 hasAuthorship W3190363003A5074619861 @default.
- W3190363003 hasConcept C134018914 @default.
- W3190363003 hasConcept C150903083 @default.
- W3190363003 hasConcept C181199279 @default.
- W3190363003 hasConcept C185592680 @default.
- W3190363003 hasConcept C195475562 @default.
- W3190363003 hasConcept C207001950 @default.
- W3190363003 hasConcept C2778004101 @default.
- W3190363003 hasConcept C2778979269 @default.
- W3190363003 hasConcept C2779280383 @default.
- W3190363003 hasConcept C538909803 @default.
- W3190363003 hasConcept C55493867 @default.
- W3190363003 hasConcept C555293320 @default.
- W3190363003 hasConcept C556039675 @default.
- W3190363003 hasConcept C71924100 @default.
- W3190363003 hasConcept C86803240 @default.
- W3190363003 hasConcept C98274493 @default.
- W3190363003 hasConceptScore W3190363003C134018914 @default.
- W3190363003 hasConceptScore W3190363003C150903083 @default.
- W3190363003 hasConceptScore W3190363003C181199279 @default.
- W3190363003 hasConceptScore W3190363003C185592680 @default.
- W3190363003 hasConceptScore W3190363003C195475562 @default.
- W3190363003 hasConceptScore W3190363003C207001950 @default.
- W3190363003 hasConceptScore W3190363003C2778004101 @default.
- W3190363003 hasConceptScore W3190363003C2778979269 @default.
- W3190363003 hasConceptScore W3190363003C2779280383 @default.
- W3190363003 hasConceptScore W3190363003C538909803 @default.
- W3190363003 hasConceptScore W3190363003C55493867 @default.
- W3190363003 hasConceptScore W3190363003C555293320 @default.
- W3190363003 hasConceptScore W3190363003C556039675 @default.
- W3190363003 hasConceptScore W3190363003C71924100 @default.
- W3190363003 hasConceptScore W3190363003C86803240 @default.
- W3190363003 hasConceptScore W3190363003C98274493 @default.
- W3190363003 hasIssue "7" @default.
- W3190363003 hasLocation W31903630031 @default.
- W3190363003 hasOpenAccess W3190363003 @default.
- W3190363003 hasPrimaryLocation W31903630031 @default.
- W3190363003 hasRelatedWork W1970538359 @default.
- W3190363003 hasRelatedWork W1979439090 @default.
- W3190363003 hasRelatedWork W1994831930 @default.
- W3190363003 hasRelatedWork W2002281820 @default.
- W3190363003 hasRelatedWork W2467179604 @default.
- W3190363003 hasRelatedWork W2555984807 @default.
- W3190363003 hasRelatedWork W2563449694 @default.
- W3190363003 hasRelatedWork W2594331030 @default.
- W3190363003 hasRelatedWork W2745105448 @default.
- W3190363003 hasRelatedWork W2763852645 @default.
- W3190363003 hasRelatedWork W2782241901 @default.
- W3190363003 hasRelatedWork W2802242732 @default.
- W3190363003 hasRelatedWork W2901052202 @default.
- W3190363003 hasRelatedWork W2972225386 @default.
- W3190363003 hasRelatedWork W2974011047 @default.
- W3190363003 hasRelatedWork W3017142395 @default.
- W3190363003 hasRelatedWork W3088231238 @default.
- W3190363003 hasRelatedWork W3100644279 @default.
- W3190363003 hasRelatedWork W2495235552 @default.
- W3190363003 hasRelatedWork W2562309128 @default.
- W3190363003 hasVolume "10" @default.
- W3190363003 isParatext "false" @default.
- W3190363003 isRetracted "false" @default.
- W3190363003 magId "3190363003" @default.
- W3190363003 workType "article" @default.