Matches in SemOpenAlex for { <https://semopenalex.org/work/W3190365857> ?p ?o ?g. }
- W3190365857 endingPage "863" @default.
- W3190365857 startingPage "847" @default.
- W3190365857 abstract "The therapeutic efficacy of stem cells transplanted into an ischaemic brain depends primarily on the responses of the neurovascular unit. Here, we report the development and applicability of a functional neurovascular unit on a microfluidic chip as a microphysiological model of ischaemic stroke that recapitulates the function of the blood-brain barrier as well as interactions between therapeutic stem cells and host cells (human brain microvascular endothelial cells, pericytes, astrocytes, microglia and neurons). We used the model to track the infiltration of a number of candidate stem cells and to characterize the expression levels of genes associated with post-stroke pathologies. We observed that each type of stem cell showed unique neurorestorative effects, primarily by supporting endogenous recovery rather than through direct cell replacement, and that the recovery of synaptic activities is correlated with the recovery of the structural and functional integrity of the neurovascular unit rather than with the regeneration of neurons." @default.
- W3190365857 created "2021-08-16" @default.
- W3190365857 creator A5012727469 @default.
- W3190365857 creator A5020779530 @default.
- W3190365857 creator A5039331709 @default.
- W3190365857 creator A5050414303 @default.
- W3190365857 creator A5054272206 @default.
- W3190365857 creator A5058481198 @default.
- W3190365857 creator A5070641652 @default.
- W3190365857 creator A5072569216 @default.
- W3190365857 creator A5077763565 @default.
- W3190365857 date "2021-08-12" @default.
- W3190365857 modified "2023-10-18" @default.
- W3190365857 title "A neurovascular-unit-on-a-chip for the evaluation of the restorative potential of stem cell therapies for ischaemic stroke" @default.
- W3190365857 cites W1465270826 @default.
- W3190365857 cites W1570720496 @default.
- W3190365857 cites W1574424832 @default.
- W3190365857 cites W1590476644 @default.
- W3190365857 cites W1667616536 @default.
- W3190365857 cites W1847104216 @default.
- W3190365857 cites W1904022644 @default.
- W3190365857 cites W1946449642 @default.
- W3190365857 cites W1975535580 @default.
- W3190365857 cites W1979741243 @default.
- W3190365857 cites W1982713565 @default.
- W3190365857 cites W1982773128 @default.
- W3190365857 cites W1989483418 @default.
- W3190365857 cites W1992396382 @default.
- W3190365857 cites W1994812037 @default.
- W3190365857 cites W2000351290 @default.
- W3190365857 cites W2003869285 @default.
- W3190365857 cites W2007883639 @default.
- W3190365857 cites W2011331227 @default.
- W3190365857 cites W2013127683 @default.
- W3190365857 cites W2014287841 @default.
- W3190365857 cites W2015541518 @default.
- W3190365857 cites W2034643457 @default.
- W3190365857 cites W2037337146 @default.
- W3190365857 cites W2048975741 @default.
- W3190365857 cites W2057151160 @default.
- W3190365857 cites W2058534130 @default.
- W3190365857 cites W2066188896 @default.
- W3190365857 cites W2070160283 @default.
- W3190365857 cites W2070264536 @default.
- W3190365857 cites W2074661552 @default.
- W3190365857 cites W2076015301 @default.
- W3190365857 cites W2076677364 @default.
- W3190365857 cites W2083004303 @default.
- W3190365857 cites W2091497743 @default.
- W3190365857 cites W2091564445 @default.
- W3190365857 cites W2091680093 @default.
- W3190365857 cites W2092021110 @default.
- W3190365857 cites W2092530725 @default.
- W3190365857 cites W2093705034 @default.
- W3190365857 cites W2098804965 @default.
- W3190365857 cites W2100545066 @default.
- W3190365857 cites W2102471194 @default.
- W3190365857 cites W2107798346 @default.
- W3190365857 cites W2129553803 @default.
- W3190365857 cites W2138152051 @default.
- W3190365857 cites W2139671059 @default.
- W3190365857 cites W2143987563 @default.
- W3190365857 cites W2145376030 @default.
- W3190365857 cites W2146336916 @default.
- W3190365857 cites W2147278993 @default.
- W3190365857 cites W2151286409 @default.
- W3190365857 cites W2153760714 @default.
- W3190365857 cites W2154555351 @default.
- W3190365857 cites W2154837723 @default.
- W3190365857 cites W2156965724 @default.
- W3190365857 cites W2159482492 @default.
- W3190365857 cites W2187990808 @default.
- W3190365857 cites W2188088979 @default.
- W3190365857 cites W2268320933 @default.
- W3190365857 cites W2277219084 @default.
- W3190365857 cites W2289500363 @default.
- W3190365857 cites W2399776559 @default.
- W3190365857 cites W2404377911 @default.
- W3190365857 cites W2404695164 @default.
- W3190365857 cites W2460090797 @default.
- W3190365857 cites W2462601649 @default.
- W3190365857 cites W2496200990 @default.
- W3190365857 cites W2501779583 @default.
- W3190365857 cites W2511446702 @default.
- W3190365857 cites W2545856467 @default.
- W3190365857 cites W2556496438 @default.
- W3190365857 cites W2558964899 @default.
- W3190365857 cites W2566732839 @default.
- W3190365857 cites W2572710398 @default.
- W3190365857 cites W2583770585 @default.
- W3190365857 cites W2592462728 @default.
- W3190365857 cites W2700330585 @default.
- W3190365857 cites W2737610481 @default.
- W3190365857 cites W2740294724 @default.
- W3190365857 cites W2755958735 @default.
- W3190365857 cites W2763146615 @default.
- W3190365857 cites W2788641685 @default.
- W3190365857 cites W2789651979 @default.