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• W3190368114 abstract "Lymphatic dysfunction is associated with the progression of several vascular disorders, though currently, there are limited strategies to promote new lymphatic vasculature (i.e., lymphangiogenesis) to restore lost lymphatic function. One promising approach to stimulate lymphangiogenesis involves delivering endothelial progenitor cells (EPCs), which are naturally involved in de novo blood vessel formation and have recently been identified to include a lymphatic subpopulation. However, the contribution of lymphatic EPCs in lymphangiogenesis is not clear and challenges with maintaining the activity of transplanted EPCs remain. Thus, the objective of this study was to isolate lymphatic EPCs from human umbilical cord blood and characterize their role in the initial stages of blood or lymphatic vasculature formation. Furthermore, this study also tested the applicability of alginate hydrogels to deliver lymphatic EPCs for a possible therapeutic application. We postulated and confirmed that blood and lymphatic EPC colonies could be isolated from human umbilical cord blood. Additionally, EPC populations responded to either angiogenic or lymphangiogenic growth factors and could stimulate their respective mature endothelial cells in vasculature models in vitro. Finally, lymphatic EPCs maintained their ability to promote lymphatic sprouts after prolonged interactions with the alginate hydrogel microenvironment. These results suggest EPCs have both a blood and a lymphatic population that have specific roles in promoting revascularization and highlight the potential of alginate hydrogels for the delivery of lymphatic EPCs. Despite the potential therapeutic benefit of promoting lymphatic vasculature, lymphangiogenesis remains understudied. One appealing strategy for promoting lymphangiogenesis involves delivering lymphatic endothelial progenitor cells (EPCs), which are a subpopulation of EPCs involved in de novo vessel formation. Here, we investigate the role of isolated blood and lymphatic EPC subpopulations in promoting the early stages of vascularization and the utility of alginate hydrogels to deliver lymphatic EPCs. We determined that EPCs had two populations that expressed either blood or lymphatic markers, could stimulate their respective mature vasculature in tissue constructs and that alginate hydrogels maintained the therapeutic potential of lymphatic EPCs. We anticipate this work could support promising biomaterial applications of EPCs to promote revascularization, which could have many therapeutic applications." @default.
• W3190368114 created "2021-08-16" @default.
• W3190368114 creator A5016808418 @default.
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• W3190368114 creator A5083051434 @default.
• W3190368114 date "2021-11-01" @default.
• W3190368114 modified "2023-09-27" @default.
• W3190368114 title "Isolating and characterizing lymphatic endothelial progenitor cells for potential therapeutic lymphangiogenic applications" @default.
• W3190368114 cites W1860019134 @default.
• W3190368114 cites W1963745369 @default.
• W3190368114 cites W1965313928 @default.
• W3190368114 cites W1972502482 @default.
• W3190368114 cites W1979103623 @default.
• W3190368114 cites W1979691822 @default.
• W3190368114 cites W1980156668 @default.
• W3190368114 cites W1981123388 @default.
• W3190368114 cites W1981987414 @default.
• W3190368114 cites W1984869225 @default.
• W3190368114 cites W1991298929 @default.
• W3190368114 cites W1992101966 @default.
• W3190368114 cites W1996575975 @default.
• W3190368114 cites W1996873726 @default.
• W3190368114 cites W1999579644 @default.
• W3190368114 cites W2001561950 @default.
• W3190368114 cites W2001658518 @default.
• W3190368114 cites W2002408287 @default.
• W3190368114 cites W2008728117 @default.
• W3190368114 cites W2014726972 @default.
• W3190368114 cites W2017311183 @default.
• W3190368114 cites W2018526639 @default.
• W3190368114 cites W2019477326 @default.
• W3190368114 cites W2019543527 @default.
• W3190368114 cites W2022282748 @default.
• W3190368114 cites W2023052504 @default.
• W3190368114 cites W2025057269 @default.
• W3190368114 cites W2028768809 @default.
• W3190368114 cites W2029134257 @default.
• W3190368114 cites W2035484369 @default.
• W3190368114 cites W2036106731 @default.
• W3190368114 cites W2036109348 @default.
• W3190368114 cites W2037580031 @default.
• W3190368114 cites W2037747858 @default.
• W3190368114 cites W2038473729 @default.
• W3190368114 cites W2044228465 @default.
• W3190368114 cites W2046513138 @default.
• W3190368114 cites W2049035024 @default.
• W3190368114 cites W2049708133 @default.
• W3190368114 cites W2051519111 @default.
• W3190368114 cites W2051534823 @default.
• W3190368114 cites W2052897104 @default.
• W3190368114 cites W2053123759 @default.
• W3190368114 cites W2053704719 @default.
• W3190368114 cites W2054635074 @default.
• W3190368114 cites W2057391188 @default.
• W3190368114 cites W2067011858 @default.
• W3190368114 cites W2067150213 @default.
• W3190368114 cites W2069537177 @default.
• W3190368114 cites W2071199205 @default.
• W3190368114 cites W2077844244 @default.
• W3190368114 cites W2079273552 @default.
• W3190368114 cites W2083402992 @default.
• W3190368114 cites W2085831434 @default.
• W3190368114 cites W2092794149 @default.
• W3190368114 cites W2095170053 @default.
• W3190368114 cites W2098743872 @default.
• W3190368114 cites W2099600327 @default.
• W3190368114 cites W2099703857 @default.
• W3190368114 cites W2107319030 @default.
• W3190368114 cites W2115830002 @default.
• W3190368114 cites W2118197922 @default.
• W3190368114 cites W2126951407 @default.
• W3190368114 cites W2138787512 @default.
• W3190368114 cites W2139837799 @default.
• W3190368114 cites W2145306368 @default.
• W3190368114 cites W2149158668 @default.
• W3190368114 cites W2149346943 @default.
• W3190368114 cites W2152442991 @default.
• W3190368114 cites W2154410414 @default.
• W3190368114 cites W2155303524 @default.
• W3190368114 cites W2155591311 @default.
• W3190368114 cites W2156985039 @default.
• W3190368114 cites W2162989910 @default.
• W3190368114 cites W2177723774 @default.
• W3190368114 cites W2315219108 @default.
• W3190368114 cites W2326768480 @default.
• W3190368114 cites W2341410391 @default.
• W3190368114 cites W2344803633 @default.
• W3190368114 cites W2598580341 @default.
• W3190368114 cites W2608476429 @default.
• W3190368114 cites W2618419720 @default.
• W3190368114 cites W2739303686 @default.
• W3190368114 cites W2753892940 @default.
• W3190368114 cites W2757105214 @default.
• W3190368114 cites W2766437645 @default.

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