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- W3190369711 abstract "Protein S100A10 participates in different cellular mechanisms and has different functions, especially at the membrane. Among those, it forms a ternary complex with annexin A2 and the C-terminal of AHNAK and then joins the dysferlin membrane repair complex. Together, they act as a platform enabling membrane repair. Both AHNAK and annexin A2 have been shown to have membrane binding properties. However, the membrane binding abilities of S100A10 are not clear. In this paper, we aimed to study the membrane binding of S100A10 in order to better understand its role in the cell membrane repair process. S100A10 was overexpressed by E. coli and purified by affinity chromatography. Using a Langmuir monolayer as a model membrane, the binding parameters and ellipsometric angles of the purified S100A10 were measured using surface tensiometry and ellipsometry, respectively. Phosphorus-31 solid-state nuclear magnetic resonance spectroscopy was also used to study the interaction of S100A10 with lipid bilayers. In the presence of a lipid monolayer, S100A10 preferentially interacts with unsaturated phospholipids. In addition, its behavior in the presence of a bilayer model suggests that S100A10 interacts more with the negatively charged polar head groups than the zwitterionic ones. This work offers new insights on the binding of S100A10 to different phospholipids and advances our understanding of the parameters influencing its membrane behavior." @default.
- W3190369711 created "2021-08-16" @default.
- W3190369711 creator A5010800148 @default.
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- W3190369711 date "2021-08-02" @default.
- W3190369711 modified "2023-10-17" @default.
- W3190369711 title "Interactions between the Cell Membrane Repair Protein S100A10 and Phospholipid Monolayers and Bilayers" @default.
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- W3190369711 doi "https://doi.org/10.1021/acs.langmuir.1c00342" @default.
- W3190369711 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34339205" @default.