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• W3190388510 abstract "Muscle function and mass begin declining in adults long before evidence of sarcopenia and include reduced mitochondrial function, although much remains to be characterized. We found that mRNA decay factor AU-rich mRNA binding factor 1 (AUF1), which stimulates myogenesis, is strongly reduced in skeletal muscle of adult and older mice in the absence of evidence of sarcopenia. Muscle-specific adeno-associated virus (AAV)8-AUF1 gene therapy increased expression of AUF1, muscle function, and mass. AAV8 AUF1 muscle gene transfer in 12-month-old mice increased the levels of activated muscle stem (satellite) cells, increased muscle mass, reduced markers of muscle atrophy, increased markers of mitochondrial content and muscle fiber oxidative capacity, and enhanced exercise performance to levels of 3-month-old mice. With wild-type and AUF1 knockout mice and cultured myoblasts, AUF1 supplementation of muscle fibers was found to increase expression of Peroxisome Proliferator-activated Receptor Gamma Co-activator 1-alpha (PGC1α), a major effector of skeletal muscle mitochondrial oxidative metabolism. AUF1 stabilized and increased translation of the pgc1α mRNA, which is strongly reduced in adult muscle in the absence of AUF1 supplementation. Skeletal muscle-specific gene transfer of AUF1 therefore restores muscle mass, increases exercise endurance, and may provide a therapeutic strategy for age-related muscle loss." @default.
• W3190388510 created "2021-08-16" @default.
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• W3190388510 date "2021-09-01" @default.
• W3190388510 modified "2023-10-15" @default.
• W3190388510 title "AUF1 gene transfer increases exercise performance and improves skeletal muscle deficit in adult mice" @default.
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• W3190388510 cites W1952579501 @default.
• W3190388510 cites W1967193288 @default.
• W3190388510 cites W1985130783 @default.
• W3190388510 cites W1990435249 @default.
• W3190388510 cites W1991156731 @default.
• W3190388510 cites W2002973721 @default.
• W3190388510 cites W2012283835 @default.
• W3190388510 cites W2012329777 @default.
• W3190388510 cites W2013060005 @default.
• W3190388510 cites W2016995077 @default.
• W3190388510 cites W2017075649 @default.
• W3190388510 cites W2029406352 @default.
• W3190388510 cites W2029706883 @default.
• W3190388510 cites W2029914169 @default.
• W3190388510 cites W2036145275 @default.
• W3190388510 cites W2050506657 @default.
• W3190388510 cites W2053765200 @default.
• W3190388510 cites W2058144592 @default.
• W3190388510 cites W2059024838 @default.
• W3190388510 cites W2062112055 @default.
• W3190388510 cites W2065054286 @default.
• W3190388510 cites W2067906234 @default.
• W3190388510 cites W2073427046 @default.
• W3190388510 cites W2074763310 @default.
• W3190388510 cites W2087299162 @default.
• W3190388510 cites W2104150966 @default.
• W3190388510 cites W2112991269 @default.
• W3190388510 cites W2113612408 @default.
• W3190388510 cites W2116456276 @default.
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• W3190388510 cites W2124499657 @default.
• W3190388510 cites W2126580445 @default.
• W3190388510 cites W2127314696 @default.
• W3190388510 cites W2130025116 @default.
• W3190388510 cites W2130932394 @default.
• W3190388510 cites W2134183508 @default.
• W3190388510 cites W2134373383 @default.
• W3190388510 cites W2136563400 @default.
• W3190388510 cites W2138896629 @default.
• W3190388510 cites W2140751228 @default.
• W3190388510 cites W2148599023 @default.
• W3190388510 cites W2157446958 @default.
• W3190388510 cites W2160211399 @default.
• W3190388510 cites W2403881977 @default.
• W3190388510 cites W2429359053 @default.
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• W3190388510 cites W2494401299 @default.
• W3190388510 cites W2556869693 @default.
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• W3190388510 cites W2742517576 @default.
• W3190388510 cites W2759818864 @default.
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• W3190388510 doi "https://doi.org/10.1016/j.omtm.2021.07.005" @default.
• W3190388510 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8399044" @default.
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