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• W3190452912 abstract "Abstract Objective The contractile behavior of collecting lymphatic vessels occurs in essential hypertension in response to homeostasis, suggesting a possible role for microcirculation. We aimed to clarify the nature of the lymphatic microcirculation profile in spontaneously hypertensive rats (SHRs) and normotensive controls. Methods The vasomotion of collecting lymphatic vessels in eight‐ and thirteen‐week‐old SHRs and age‐matched Wistar‐Kyoto rats (WKYs, n = 4 per group) was visualized by intravital video and VasTrack. The lymphatic vasomotion profile (frequency and amplitude) and contractile parameters (contraction fraction and total contractility activity index) were compared. Plasma nitrite/nitrate levels were assessed by the Griess reaction, and plasma endothelin‐1 was measured by enzyme‐linked immunosorbent assay. Results WKYs and SHRs differed in the vasomotion of collecting lymphatic vessels. Both eight‐ and thirteen‐week‐old WKYs revealed a high‐amplitude pumping pattern, whereas a low‐amplitude pattern was observed in SHRs. Moreover, compared with age‐matched WKYs, SHRs exhibited deteriorated output and reflux capability and lost the ability to regulate collecting lymphatic vasomotion. Additionally, the chemistry complements the microcirculatory lymphatic profile as demonstrated by an increase in plasma nitrite, nitrate, and endothelin‐1 in SHRs. ET‐1 inhibitor meliorated the lymphatic contractile capability in SHRs partially through regulating frequency of lymphatic vasomotion. Conclusions We used an intravital lymphatic imaging system to observe that SHRs exhibit an impaired collecting lymphatic vasomotion profile and deteriorated contractility and reflux." @default.
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• W3190452912 date "2021-08-17" @default.
• W3190452912 modified "2023-10-18" @default.
• W3190452912 title "Lymphatic microcirculation profile in the progression of hypertension in spontaneously hypertensive rats" @default.
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• W3190452912 doi "https://doi.org/10.1111/micc.12724" @default.
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