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- W3190468800 abstract "Abstract The vasculature is a key component of adult brain neural stem cell (NSC) niches. In the adult mammalian hippocampus, NSCs reside in close contact with a dense capillary network. How this niche is maintained is unclear. We recently found that adult hippocampal NSCs express vascular endothelial growth factor (VEGF), a soluble factor with chemoattractive properties for vascular endothelia. Here, we show that NSC-specific VEGF loss led to dissociation of NSCs from local vasculature but surprisingly found no changes in vascular density. Instead, we found that NSC-derived VEGF supports the motility of NSCs themselves via a cell internal signaling loop. We further found that this internal autocrine loop also independently maintained NSC quiescence cell autonomously. Combined, our findings suggest that NSCs maintain their populations via 2 mechanisms that are dependent on cell internal VEGF signaling: self-stimulated motility towards vasculature and cell autonomous maintenance of quiescence programs." @default.
- W3190468800 created "2021-08-16" @default.
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- W3190468800 date "2021-08-10" @default.
- W3190468800 modified "2023-10-17" @default.
- W3190468800 title "Intracrine Vascular Endothelial Growth Factor Maintains Hippocampal Neural Stem Cell Quiescence" @default.
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- W3190468800 doi "https://doi.org/10.1101/2021.08.10.455866" @default.
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