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Matches in SemOpenAlex for { <https://semopenalex.org/work/W3190495890> ?p ?o ?g. }

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• W3190495890 abstract "The alkaloid physostigmine is an approved anticholinergic drug and an important lead structure for the development of novel therapeutics. Using a complementary approach that merged chemical synthesis with pathway refactoring, we produced a series of physostigmine analogues with altered specificity and toxicity profiles in the heterologous host Myxococcus xanthus. The compounds that were generated by applying a simple feeding strategy include the promising drug candidate phenserine, which was previously accessible only by total synthesis." @default.
• W3190495890 created "2021-08-16" @default.
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• W3190495890 date "2021-08-06" @default.
• W3190495890 modified "2023-10-18" @default.
• W3190495890 title "Mutasynthesis of Physostigmines in <i>Myxococcus xanthus</i>" @default.
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• W3190495890 doi "https://doi.org/10.1021/acs.orglett.1c02374" @default.
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