Matches in SemOpenAlex for { <https://semopenalex.org/work/W3190509519> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W3190509519 abstract "Abstract More than 2 million SARS-CoV-2 genome sequences have been generated and shared since the start of the COVID-19 pandemic and constitute a vital information source that informs outbreak control, disease surveillance, and public health policy. The Pango dynamic nomenclature is a popular system for classifying and naming genetically-distinct lineages of SARS-CoV-2, including variants of concern, and is based on the analysis of complete or near-complete virus genomes. However, for several reasons, nucleotide sequences may be generated that cover only the spike gene of SARS-CoV-2. It is therefore important to understand how much information about Pango lineage status is contained in spike-only nucleotide sequences. Here we explore how Pango lineages might be reliably designated and assigned to spike-only nucleotide sequences. We survey the genetic diversity of such sequences, and investigate the information they contain about Pango lineage status. Although many lineages, including the main variants of concern, can be identified clearly using spike-only sequences, some spike-only sequences are shared among tens or hundreds of Pango lineages. To facilitate the classification of SARS-CoV-2 lineages using subgenomic sequences we introduce the notion of designating such sequences to a “lineage set”, which represents the range of Pango lineages that are consistent with the observed mutations in a given spike sequence. These data provide a foundation for the development of software tools that can assign newly-generated spike nucleotide sequences to Pango lineage sets." @default.
- W3190509519 created "2021-08-16" @default.
- W3190509519 creator A5016425024 @default.
- W3190509519 creator A5064719195 @default.
- W3190509519 creator A5070656676 @default.
- W3190509519 creator A5083534383 @default.
- W3190509519 date "2021-08-10" @default.
- W3190509519 modified "2023-10-17" @default.
- W3190509519 title "Pango lineage designation and assignment using SARS-CoV-2 spike gene nucleotide sequences" @default.
- W3190509519 cites W1768287364 @default.
- W3190509519 cites W2096347191 @default.
- W3190509519 cites W2605343262 @default.
- W3190509519 cites W2789843538 @default.
- W3190509519 cites W3043124965 @default.
- W3190509519 cites W3092136311 @default.
- W3190509519 cites W3111342687 @default.
- W3190509519 cites W3119321472 @default.
- W3190509519 cites W3135383916 @default.
- W3190509519 cites W3140799430 @default.
- W3190509519 cites W3156343712 @default.
- W3190509519 cites W3176596141 @default.
- W3190509519 cites W3180301457 @default.
- W3190509519 cites W3195362455 @default.
- W3190509519 cites W4211043793 @default.
- W3190509519 doi "https://doi.org/10.1101/2021.08.10.455799" @default.
- W3190509519 hasPublicationYear "2021" @default.
- W3190509519 type Work @default.
- W3190509519 sameAs 3190509519 @default.
- W3190509519 citedByCount "2" @default.
- W3190509519 countsByYear W31905095192021 @default.
- W3190509519 countsByYear W31905095192023 @default.
- W3190509519 crossrefType "posted-content" @default.
- W3190509519 hasAuthorship W3190509519A5016425024 @default.
- W3190509519 hasAuthorship W3190509519A5064719195 @default.
- W3190509519 hasAuthorship W3190509519A5070656676 @default.
- W3190509519 hasAuthorship W3190509519A5083534383 @default.
- W3190509519 hasBestOaLocation W31905095191 @default.
- W3190509519 hasConcept C104317684 @default.
- W3190509519 hasConcept C115903868 @default.
- W3190509519 hasConcept C141231307 @default.
- W3190509519 hasConcept C189819185 @default.
- W3190509519 hasConcept C2776817793 @default.
- W3190509519 hasConcept C2781390188 @default.
- W3190509519 hasConcept C41008148 @default.
- W3190509519 hasConcept C51679486 @default.
- W3190509519 hasConcept C54355233 @default.
- W3190509519 hasConcept C70721500 @default.
- W3190509519 hasConcept C78458016 @default.
- W3190509519 hasConcept C86803240 @default.
- W3190509519 hasConceptScore W3190509519C104317684 @default.
- W3190509519 hasConceptScore W3190509519C115903868 @default.
- W3190509519 hasConceptScore W3190509519C141231307 @default.
- W3190509519 hasConceptScore W3190509519C189819185 @default.
- W3190509519 hasConceptScore W3190509519C2776817793 @default.
- W3190509519 hasConceptScore W3190509519C2781390188 @default.
- W3190509519 hasConceptScore W3190509519C41008148 @default.
- W3190509519 hasConceptScore W3190509519C51679486 @default.
- W3190509519 hasConceptScore W3190509519C54355233 @default.
- W3190509519 hasConceptScore W3190509519C70721500 @default.
- W3190509519 hasConceptScore W3190509519C78458016 @default.
- W3190509519 hasConceptScore W3190509519C86803240 @default.
- W3190509519 hasLocation W31905095191 @default.
- W3190509519 hasLocation W31905095192 @default.
- W3190509519 hasLocation W31905095193 @default.
- W3190509519 hasOpenAccess W3190509519 @default.
- W3190509519 hasPrimaryLocation W31905095191 @default.
- W3190509519 hasRelatedWork W1603543036 @default.
- W3190509519 hasRelatedWork W2061004617 @default.
- W3190509519 hasRelatedWork W2069184423 @default.
- W3190509519 hasRelatedWork W2131211314 @default.
- W3190509519 hasRelatedWork W2979909390 @default.
- W3190509519 hasRelatedWork W3088126680 @default.
- W3190509519 hasRelatedWork W4229549692 @default.
- W3190509519 hasRelatedWork W4255542154 @default.
- W3190509519 hasRelatedWork W4362593364 @default.
- W3190509519 hasRelatedWork W2187207551 @default.
- W3190509519 isParatext "false" @default.
- W3190509519 isRetracted "false" @default.
- W3190509519 magId "3190509519" @default.
- W3190509519 workType "article" @default.