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- W3190535612 abstract "Tailed double-stranded DNA bacteriophages inject some proteins with their dsDNA during infection. Phage P22 injects about 12, 12, and 30 molecules of the proteins encoded by genes 7, 16 and 20, respectively. After their ejection from the virion, they assemble into a trans-periplasmic conduit through which the DNA passes to enter the cytoplasm. The location of these proteins in the virion before injection is not well understood, although we recently showed they reside near the portal protein barrel in DNA-filled heads. In this report we show that when these proteins are missing from the virion, a longer than normal DNA molecule is encapsidated by the P22 headful DNA packaging machinery. Thus, the ejection proteins occupy positions within the virion that can be occupied by packaged DNA when they are absent." @default.
- W3190535612 created "2021-08-16" @default.
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- W3190535612 creator A5044911524 @default.
- W3190535612 creator A5064937729 @default.
- W3190535612 creator A5081637587 @default.
- W3190535612 date "2021-07-30" @default.
- W3190535612 modified "2023-10-18" @default.
- W3190535612 title "Intravirion DNA Can Access the Space Occupied by the Bacteriophage P22 Ejection Proteins" @default.
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- W3190535612 doi "https://doi.org/10.3390/v13081504" @default.
- W3190535612 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8402733" @default.
- W3190535612 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34452369" @default.
- W3190535612 hasPublicationYear "2021" @default.
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