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- W3190553164 abstract "Introduction: Intraocular Pressure (IOP) is reported to rise during Parabolic and Space Flights and also during simulation of microgravity in form of Head Down Tilt. However, no study has ever examined IOP changes during Dry Floatation (DF). Additionally, concern that it may be associated with transient impairment of Visual Acuity has also not been addressed, adequately. The study was to examine changes in Intra Ocular Pressure (IOP) and Visual Acuity during microgravity simulation, in the form of thermoneutral (34.5 –35.5oC), supine Dry Floatation, for 6 hours. Methods: IOP, Visual Acuity, Thoracic Impedance, Heart Rate and MAP were measured during DF (20 min, 40 min, 60 min, 120 min, 240 min and 360 min) in 12 healthy male volunteers (28-39 yrs) and compared with baseline values in a ground based supine posture. Additionally, IOP was measured in 6 subjects (n=12 eyes), maintained in a ground based supine posture for 2 hours (every 30 min), to examine the repeatability of the instrument (Keelar Pulsair Non Contact tonometer). Results were analysed using repeated measure ANOVA. Results: IOP did not change with the progression of ground based supine posture (F= 0.996; p= 0.413). During DF, IOP changed significantly (F= 13.45; p= 0.000). The values at 20 min and 40 min (19.7 ± 2.9 mm Hg, 19.4 ± 3.2 mm Hg, respectively) were significantly higher (p=0.000, p= 0.001, respectively) than baseline supine values (17.2 ± 3.2 mm Hg). The increase in IOP was much less pronounced than that reported in parabolic or space flights. Values after 60 min of DF were not different (p=0.061), and values during recovery were lower (p=0.008) than supine values. Thoracic Impedance remained higher than baseline values throughout the DF (F=7.747; p=0.001) indicating haemodilution. There was a significant decrease in Heart Rate and MAP that was evident throughout the six hrs of DF (F = 4.476; p=0.011 and F = 3.627; p= 0.021, respectively). However, IOP correlated poorly with Thoracic Impedance (r = -0.06; NS). There was no change in distant or near visual acuity was observed. Conclusion: Supine Dry Floatation results into a small and transient increase in IOP, which is not associated with changes in visual acuity. The changes are also not correlated with the extent of haemodilution." @default.
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- W3190553164 date "2015-06-30" @default.
- W3190553164 modified "2023-09-23" @default.
- W3190553164 title "Intraocular Pressure and Visual Acuity Changes during 6 hours of Simulated Microgravity by Dry Floatation" @default.
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