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- W3190558770 abstract "Abstract Background Mycobacteroides abscessus ( M. abscessus ) is the most commonly isolated rapidly growing mycobacteria (RGM) and is one of the most antibiotic-resistant RGM with rapid progression, therefore, treatment of M. abscessus is still challenging. The genus mycobacterium has long been known to have both rough and smooth colony phenotypes. Rough morphotypes generally are more virulent than smooth morphotypes. Recently, the efficacy of sitafloxacin, new fluoroquinolone (FQ), containing regimens against M. abscessus complex have been reported. We here presented a new combination treatment with sitafloxacin that targeted rough morphotypes of M. abscessus , causing aggressive infections. Results Thirty-four clinical strains of M. abscessus were isolated from various clinical samples at the Juntendo university hospital from 2011 to 2020. The susceptibility to a combination of sitafloxacin and antimicrobial agents was compared to that of the antimicrobial agents alone. Ten isolates (90.9%) of M. abscessus subsp. abscessus were susceptible to both sitafloxacin and arbekacin when the combination is administered; while, 11 isolates (50.0%) of M. abscessus subsp. massiliense were susceptible. Synergistic effects against M. abscessus complex were shown in 8 strains (23.5%) treated with sitafloxacin-amikacin combination, 9 (26.5%) and 19 (55.9%) of sitafloxacin-imipenem combination, and sitafloxacin-arbekacin combination, respectively. Sitafloxacin-arbekacin combination also exhibited synergistic effects against 10 strains (45.5%) of M. abscessus subsp. massiliense and 8 stains (72.7%) of M. abscessus subsp. abscessus , a highly resistant subspecies of M. abscessus. The sitafloxacin-arbekacin combination revealed more synergistic effects in rough morphotypes of M. abscessus complex ( p = 0.008). Conclusion We demonstrated the synergistic effect of the sitafloxacin-arbekacin combination against M. abscessus complex. Further, this combination regimen might be more effective against M. abscessus subsp. abscessus or rough morphotypes of M. abscessus complex." @default.
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- W3190558770 date "2021-08-05" @default.
- W3190558770 modified "2023-10-18" @default.
- W3190558770 title "The Synergetic Effect of Sitafloxacin-Arbekacin Combination in the Mycobacteroides abscessus Complex" @default.
- W3190558770 doi "https://doi.org/10.21203/rs.3.rs-767954/v1" @default.
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