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- W3190569063 endingPage "923.e6" @default.
- W3190569063 startingPage "907" @default.
- W3190569063 abstract "eIF4F plays diverse roles in human cancers, which complicate the development of an overarching understanding of its functional and regulatory impacts across tumor types. Typically, eIF4F drives initiation from the mRNA 5' end (cap) and is composed of eIF4G1, eIF4A1, and cap-binding eIF4E. Cap-independent initiation is possible without eIF4E, from internal ribosomal entry sites (IRESs). By analyzing large public datasets, we found that cancers selectively overexpress EIF4G1 more than EIF4E. That expression imbalance supports EIF4G1 as a prognostic indicator in patients with cancer. It also attenuates housekeeping pathways that are usually regulated in a tissue-specific manner via cap-dependent initiation in healthy tissues and reinforce regulation of cancer-preferred pathways in cap-independent contexts. Cap-independent initiation is mechanistically attributable to eIF4G1 hyperphosphorylation that promotes binding to eIF4A1 and reduced eIF4E availability. Collectively, these findings reveal a novel model of dysregulated eIF4F function and highlight the clinical relevance of cap-(in)dependent initiation in cancer." @default.
- W3190569063 created "2021-08-16" @default.
- W3190569063 creator A5012973484 @default.
- W3190569063 creator A5090569228 @default.
- W3190569063 date "2021-09-01" @default.
- W3190569063 modified "2023-10-18" @default.
- W3190569063 title "Deep computational analysis details dysregulation of eukaryotic translation initiation complex eIF4F in human cancers" @default.
- W3190569063 cites W1516043257 @default.
- W3190569063 cites W1816176398 @default.
- W3190569063 cites W1902360513 @default.
- W3190569063 cites W1922815468 @default.
- W3190569063 cites W1965894414 @default.
- W3190569063 cites W1968523385 @default.
- W3190569063 cites W1969372234 @default.
- W3190569063 cites W1969473557 @default.
- W3190569063 cites W1969974585 @default.
- W3190569063 cites W1974434328 @default.
- W3190569063 cites W1982599843 @default.
- W3190569063 cites W1987499203 @default.
- W3190569063 cites W1993844923 @default.
- W3190569063 cites W2005033230 @default.
- W3190569063 cites W2005056727 @default.
- W3190569063 cites W2008239768 @default.
- W3190569063 cites W2008410413 @default.
- W3190569063 cites W2010355074 @default.
- W3190569063 cites W2011961482 @default.
- W3190569063 cites W2013385077 @default.
- W3190569063 cites W2016107719 @default.
- W3190569063 cites W2028548180 @default.
- W3190569063 cites W2029165441 @default.
- W3190569063 cites W2040885133 @default.
- W3190569063 cites W2043398720 @default.
- W3190569063 cites W2051542850 @default.
- W3190569063 cites W2053894178 @default.
- W3190569063 cites W2057906496 @default.
- W3190569063 cites W2070329174 @default.
- W3190569063 cites W2074820129 @default.
- W3190569063 cites W2075362559 @default.
- W3190569063 cites W2088695488 @default.
- W3190569063 cites W2089238459 @default.
- W3190569063 cites W2096184369 @default.
- W3190569063 cites W2097102109 @default.
- W3190569063 cites W2102028478 @default.
- W3190569063 cites W2110364290 @default.
- W3190569063 cites W2112013596 @default.
- W3190569063 cites W2115804977 @default.
- W3190569063 cites W2116324169 @default.
- W3190569063 cites W2119549758 @default.
- W3190569063 cites W2125666085 @default.
- W3190569063 cites W2127983466 @default.
- W3190569063 cites W2128551987 @default.
- W3190569063 cites W2128677683 @default.
- W3190569063 cites W2133856510 @default.
- W3190569063 cites W2135479242 @default.
- W3190569063 cites W2137383307 @default.
- W3190569063 cites W2138016026 @default.
- W3190569063 cites W2140254301 @default.
- W3190569063 cites W2142374550 @default.
- W3190569063 cites W2142493220 @default.
- W3190569063 cites W2142505369 @default.
- W3190569063 cites W2143160922 @default.
- W3190569063 cites W2148297062 @default.
- W3190569063 cites W2149148435 @default.
- W3190569063 cites W2157852151 @default.
- W3190569063 cites W2158485828 @default.
- W3190569063 cites W2158945729 @default.
- W3190569063 cites W2160079255 @default.
- W3190569063 cites W2162361253 @default.
- W3190569063 cites W2163521032 @default.
- W3190569063 cites W2165341580 @default.
- W3190569063 cites W2165806251 @default.
- W3190569063 cites W2166091404 @default.
- W3190569063 cites W2264806126 @default.
- W3190569063 cites W2395887422 @default.
- W3190569063 cites W2434972413 @default.
- W3190569063 cites W2485377503 @default.
- W3190569063 cites W2538475718 @default.
- W3190569063 cites W2593816418 @default.
- W3190569063 cites W2606717848 @default.
- W3190569063 cites W2607211817 @default.
- W3190569063 cites W2625964693 @default.
- W3190569063 cites W2795686629 @default.
- W3190569063 cites W2795989238 @default.
- W3190569063 cites W2802413845 @default.
- W3190569063 cites W2884774015 @default.
- W3190569063 cites W2947561691 @default.
- W3190569063 cites W2950638233 @default.
- W3190569063 cites W2951890467 @default.
- W3190569063 cites W2957355938 @default.
- W3190569063 cites W3000435127 @default.
- W3190569063 cites W3001475835 @default.
- W3190569063 cites W3028304854 @default.
- W3190569063 cites W3041397352 @default.
- W3190569063 cites W4252414615 @default.
- W3190569063 cites W4253376202 @default.
- W3190569063 cites W4376849723 @default.
- W3190569063 doi "https://doi.org/10.1016/j.cels.2021.07.002" @default.
- W3190569063 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8460614" @default.