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- W3190647204 abstract "Adaptor molecules lack enzymatic and transcriptional activities. Instead, they exert their function by linking multiple proteins into intricate complexes, allowing for transmitting and fine-tuning of signals. Many adaptor molecules play a crucial role in T-cell signaling, following engagement of the T-cell receptor (TCR). In this review, we focus on Linker of Activation of T cells (LAT) and SH2 domain-containing leukocyte protein of 76 KDa (SLP-76). Monogenic defects in these adaptor proteins, with known roles in T-cell signaling, have been described as the cause of human inborn errors of immunity (IEI). We describe the current knowledge based on defects in cell lines, murine models and human patients. Germline mutations in Adhesion and degranulation adaptor protein (ADAP), have not resulted in a T-cell defect." @default.
- W3190647204 created "2021-08-16" @default.
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- W3190647204 creator A5086624955 @default.
- W3190647204 date "2021-08-12" @default.
- W3190647204 modified "2023-09-25" @default.
- W3190647204 title "The Clinical Aspect of Adaptor Molecules in T Cell Signaling: Lessons Learnt From Inborn Errors of Immunity" @default.
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- W3190647204 cites W1521662765 @default.
- W3190647204 cites W1559516752 @default.
- W3190647204 cites W1657823335 @default.
- W3190647204 cites W1693076983 @default.
- W3190647204 cites W1699431440 @default.
- W3190647204 cites W1788605047 @default.
- W3190647204 cites W1854247600 @default.
- W3190647204 cites W1950594001 @default.
- W3190647204 cites W1966251842 @default.
- W3190647204 cites W1983635410 @default.
- W3190647204 cites W1990634604 @default.
- W3190647204 cites W1992438206 @default.
- W3190647204 cites W2002943653 @default.
- W3190647204 cites W2005525391 @default.
- W3190647204 cites W2010435020 @default.
- W3190647204 cites W2016809573 @default.
- W3190647204 cites W2019331069 @default.
- W3190647204 cites W2020700385 @default.
- W3190647204 cites W2024891824 @default.
- W3190647204 cites W2025371598 @default.
- W3190647204 cites W2030254950 @default.
- W3190647204 cites W2040098705 @default.
- W3190647204 cites W2043208930 @default.
- W3190647204 cites W2047342342 @default.
- W3190647204 cites W2050111332 @default.
- W3190647204 cites W2057024012 @default.
- W3190647204 cites W2058118641 @default.
- W3190647204 cites W2059942477 @default.
- W3190647204 cites W2061946691 @default.
- W3190647204 cites W2067752213 @default.
- W3190647204 cites W2073526321 @default.
- W3190647204 cites W2075279346 @default.
- W3190647204 cites W2077518158 @default.
- W3190647204 cites W2077648546 @default.
- W3190647204 cites W2078714832 @default.
- W3190647204 cites W2081613818 @default.
- W3190647204 cites W2082404058 @default.
- W3190647204 cites W2087107586 @default.
- W3190647204 cites W2090514048 @default.
- W3190647204 cites W2096613461 @default.
- W3190647204 cites W2098325534 @default.
- W3190647204 cites W2098409714 @default.
- W3190647204 cites W2100412095 @default.
- W3190647204 cites W2100646106 @default.
- W3190647204 cites W2102536703 @default.
- W3190647204 cites W2104431870 @default.
- W3190647204 cites W2106251488 @default.
- W3190647204 cites W2107815927 @default.
- W3190647204 cites W2109479443 @default.
- W3190647204 cites W2113520409 @default.
- W3190647204 cites W2119731343 @default.
- W3190647204 cites W2125337252 @default.
- W3190647204 cites W2129013406 @default.
- W3190647204 cites W2131673648 @default.
- W3190647204 cites W2132557087 @default.
- W3190647204 cites W2137561154 @default.
- W3190647204 cites W2143600483 @default.
- W3190647204 cites W2146167386 @default.
- W3190647204 cites W2148712172 @default.
- W3190647204 cites W2149650496 @default.
- W3190647204 cites W2152093499 @default.
- W3190647204 cites W2154969164 @default.
- W3190647204 cites W2158947557 @default.
- W3190647204 cites W2161596417 @default.
- W3190647204 cites W2161946035 @default.
- W3190647204 cites W2165718358 @default.
- W3190647204 cites W2412861620 @default.
- W3190647204 cites W2466190463 @default.
- W3190647204 cites W2470425466 @default.
- W3190647204 cites W2586291194 @default.
- W3190647204 cites W2597245513 @default.
- W3190647204 cites W2807821842 @default.
- W3190647204 cites W2807836515 @default.
- W3190647204 cites W2810624928 @default.
- W3190647204 cites W2884317633 @default.
- W3190647204 cites W2896866335 @default.
- W3190647204 cites W2962067817 @default.
- W3190647204 cites W2984650450 @default.
- W3190647204 cites W3094721846 @default.
- W3190647204 cites W3110394972 @default.
- W3190647204 cites W4253930413 @default.
- W3190647204 cites W1955399772 @default.
- W3190647204 doi "https://doi.org/10.3389/fimmu.2021.701704" @default.
- W3190647204 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8397411" @default.
- W3190647204 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34456914" @default.
- W3190647204 hasPublicationYear "2021" @default.
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