FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3190673670> ?p ?o ?g. }

• W3190673670 endingPage "120962" @default.
• W3190673670 startingPage "120962" @default.
• W3190673670 abstract "Drug-excipient compatibility study is the essential basis for excipient selection at the pre-formulation stage. According to the pharmaceutical Quality by Design (QbD) principles, a comprehensive understanding of the ingredients' physicochemical properties and a theoretical evaluation of the interaction risk between the drugs and excipients are required for conducting rational compatibility experimental design. Currently, there is an urgent need to establish an artificial intelligence system for researchers to easily get through the problem because it is very inconvenient and hard to utilize those drug-excipient incompatibility data scattered in scientific literature. Here, we designed a knowledge-driven expert system named PharmDE for drug-excipient incompatibility risk evaluation. PharmDE firstly developed an information-rich database to store incompatibility data, covering 532 data items from 228 selected articles. Then, 60 drug-excipient interaction rules were created based on our knowledge and formulation research experiences. Finally, the expert system was developed by organically integrating the database searching and rule-based incompatibility risk prediction, which resulted in four main functionalities: basic search of incompatibility database, data matching by similarity search, drug incompatibility risk evaluation, and formulation incompatibility risk evaluation. PharmDE is expected to be a useful tool for drug-excipient compatibility study and accelerate drug formulation design. It is now freely available at https://pharmde.computpharm.org." @default.
• W3190673670 created "2021-08-16" @default.
• W3190673670 creator A5004795100 @default.
• W3190673670 creator A5024615233 @default.
• W3190673670 creator A5072308291 @default.
• W3190673670 creator A5086045569 @default.
• W3190673670 date "2021-09-01" @default.
• W3190673670 modified "2023-10-01" @default.
• W3190673670 title "PharmDE: A new expert system for drug-excipient compatibility evaluation" @default.
• W3190673670 cites W1971332595 @default.
• W3190673670 cites W1975147762 @default.
• W3190673670 cites W2003848392 @default.
• W3190673670 cites W2008067932 @default.
• W3190673670 cites W2016612023 @default.
• W3190673670 cites W2023060419 @default.
• W3190673670 cites W2025592056 @default.
• W3190673670 cites W2025672323 @default.
• W3190673670 cites W2040103915 @default.
• W3190673670 cites W2047909810 @default.
• W3190673670 cites W2061977564 @default.
• W3190673670 cites W2076968775 @default.
• W3190673670 cites W2077795896 @default.
• W3190673670 cites W2080712021 @default.
• W3190673670 cites W2088200912 @default.
• W3190673670 cites W2091483354 @default.
• W3190673670 cites W2091849182 @default.
• W3190673670 cites W2096541451 @default.
• W3190673670 cites W2119831922 @default.
• W3190673670 cites W2127553917 @default.
• W3190673670 cites W2195203261 @default.
• W3190673670 cites W2313253053 @default.
• W3190673670 cites W2330372519 @default.
• W3190673670 cites W2335792484 @default.
• W3190673670 cites W2496839529 @default.
• W3190673670 cites W2756644365 @default.
• W3190673670 cites W2767492614 @default.
• W3190673670 cites W2774547990 @default.
• W3190673670 cites W2944375531 @default.
• W3190673670 cites W2944677242 @default.
• W3190673670 cites W2971199424 @default.
• W3190673670 cites W3011127514 @default.
• W3190673670 cites W3011143677 @default.
• W3190673670 cites W3013269370 @default.
• W3190673670 cites W3097774983 @default.
• W3190673670 cites W4231366709 @default.
• W3190673670 doi "https://doi.org/10.1016/j.ijpharm.2021.120962" @default.
• W3190673670 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34339812" @default.
• W3190673670 hasPublicationYear "2021" @default.
• W3190673670 type Work @default.
• W3190673670 sameAs 3190673670 @default.
• W3190673670 citedByCount "10" @default.
• W3190673670 countsByYear W31906736702021 @default.
• W3190673670 countsByYear W31906736702022 @default.
• W3190673670 countsByYear W31906736702023 @default.
• W3190673670 crossrefType "journal-article" @default.
• W3190673670 hasAuthorship W3190673670A5004795100 @default.
• W3190673670 hasAuthorship W3190673670A5024615233 @default.
• W3190673670 hasAuthorship W3190673670A5072308291 @default.
• W3190673670 hasAuthorship W3190673670A5086045569 @default.
• W3190673670 hasConcept C112930515 @default.
• W3190673670 hasConcept C127413603 @default.
• W3190673670 hasConcept C154945302 @default.
• W3190673670 hasConcept C183696295 @default.
• W3190673670 hasConcept C204320433 @default.
• W3190673670 hasConcept C21547014 @default.
• W3190673670 hasConcept C2776207758 @default.
• W3190673670 hasConcept C2777239854 @default.
• W3190673670 hasConcept C2778648169 @default.
• W3190673670 hasConcept C2780035454 @default.
• W3190673670 hasConcept C41008148 @default.
• W3190673670 hasConcept C42360764 @default.
• W3190673670 hasConcept C58328972 @default.
• W3190673670 hasConcept C71924100 @default.
• W3190673670 hasConcept C98274493 @default.
• W3190673670 hasConceptScore W3190673670C112930515 @default.
• W3190673670 hasConceptScore W3190673670C127413603 @default.
• W3190673670 hasConceptScore W3190673670C154945302 @default.
• W3190673670 hasConceptScore W3190673670C183696295 @default.
• W3190673670 hasConceptScore W3190673670C204320433 @default.
• W3190673670 hasConceptScore W3190673670C21547014 @default.
• W3190673670 hasConceptScore W3190673670C2776207758 @default.
• W3190673670 hasConceptScore W3190673670C2777239854 @default.
• W3190673670 hasConceptScore W3190673670C2778648169 @default.
• W3190673670 hasConceptScore W3190673670C2780035454 @default.
• W3190673670 hasConceptScore W3190673670C41008148 @default.
• W3190673670 hasConceptScore W3190673670C42360764 @default.
• W3190673670 hasConceptScore W3190673670C58328972 @default.
• W3190673670 hasConceptScore W3190673670C71924100 @default.
• W3190673670 hasConceptScore W3190673670C98274493 @default.
• W3190673670 hasFunder F4320321540 @default.
• W3190673670 hasFunder F4320322841 @default.
• W3190673670 hasFunder F4320323893 @default.
• W3190673670 hasLocation W31906736701 @default.
• W3190673670 hasOpenAccess W3190673670 @default.
• W3190673670 hasPrimaryLocation W31906736701 @default.
• W3190673670 hasRelatedWork W1973600800 @default.
• W3190673670 hasRelatedWork W1994624055 @default.
• W3190673670 hasRelatedWork W2016612023 @default.

• next