FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3190703354> ?p ?o ?g. }

• W3190703354 abstract "Cardiovascular pathology is often accompanied by changes in relative content and/or ratios of structural extracellular matrix (ECM) proteins within the heart and elastic vessels. Three of these proteins, collagen-I, collagen-III, and elastin, make up the bulk of the ECM proteins in these tissues, forming a microenvironment that strongly dictates the tissue biomechanical properties and effectiveness of cardiac and vascular function. In this review, we aim to elucidate how the ratios of collagen-I to collagen-III and elastin to collagen are altered in cardiovascular diseases and the aged individuum. We elaborate on these major cardiovascular ECM proteins in terms of structure, tissue localization, turnover, and physiological function and address how their ratios change in aging, dilated cardiomyopathy, coronary artery disease with myocardial infarction, atrial fibrillation, aortic aneurysms, atherosclerosis, and hypertension. To the end of guiding in vitro modeling approaches, we focus our review on the human heart and aorta, discuss limitations in ECM protein quantification methodology, examine comparability between studies, and highlight potential in vitro applications. In summary, we found collagen-I relative concentration to increase or stay the same in cardiovascular disease, resulting in a tendency for increased collagen-I/collagen-III and decreased elastin/collagen ratios. These ratios were found to fall on a continuous scale with ranges defining distinct pathological states as well as a significant difference between the human heart and aortic ECM protein ratios." @default.
• W3190703354 created "2021-08-16" @default.
• W3190703354 creator A5018187010 @default.
• W3190703354 creator A5065965249 @default.
• W3190703354 date "2021-08-04" @default.
• W3190703354 modified "2023-10-03" @default.
• W3190703354 title "Extracellular Matrix Protein Ratios in the Human Heart and Vessels: How to Distinguish Pathological From Physiological Changes?" @default.
• W3190703354 cites W13596244 @default.
• W3190703354 cites W1488575885 @default.
• W3190703354 cites W1497266024 @default.
• W3190703354 cites W1556661044 @default.
• W3190703354 cites W1827569473 @default.
• W3190703354 cites W1964923925 @default.
• W3190703354 cites W1967015050 @default.
• W3190703354 cites W1973027424 @default.
• W3190703354 cites W1976236115 @default.
• W3190703354 cites W1976562969 @default.
• W3190703354 cites W1977603474 @default.
• W3190703354 cites W1978582021 @default.
• W3190703354 cites W1978729944 @default.
• W3190703354 cites W1985276869 @default.
• W3190703354 cites W1988665275 @default.
• W3190703354 cites W1988875780 @default.
• W3190703354 cites W1989383397 @default.
• W3190703354 cites W1991210318 @default.
• W3190703354 cites W1992873457 @default.
• W3190703354 cites W1993708187 @default.
• W3190703354 cites W1993869526 @default.
• W3190703354 cites W1998654497 @default.
• W3190703354 cites W2000856419 @default.
• W3190703354 cites W2003197337 @default.
• W3190703354 cites W2004316511 @default.
• W3190703354 cites W2005212592 @default.
• W3190703354 cites W2006062168 @default.
• W3190703354 cites W2009808606 @default.
• W3190703354 cites W2012957301 @default.
• W3190703354 cites W2017666901 @default.
• W3190703354 cites W2021518713 @default.
• W3190703354 cites W2023394535 @default.
• W3190703354 cites W2023844858 @default.
• W3190703354 cites W2031203524 @default.
• W3190703354 cites W2033020488 @default.
• W3190703354 cites W2034110426 @default.
• W3190703354 cites W2037671352 @default.
• W3190703354 cites W2045295282 @default.
• W3190703354 cites W2048497399 @default.
• W3190703354 cites W2049235717 @default.
• W3190703354 cites W2050729995 @default.
• W3190703354 cites W2051655002 @default.
• W3190703354 cites W2052782072 @default.
• W3190703354 cites W2053945568 @default.
• W3190703354 cites W2055005497 @default.
• W3190703354 cites W2060018075 @default.
• W3190703354 cites W2065593981 @default.
• W3190703354 cites W2071251073 @default.
• W3190703354 cites W2074565414 @default.
• W3190703354 cites W2091607049 @default.
• W3190703354 cites W2094395194 @default.
• W3190703354 cites W2104367193 @default.
• W3190703354 cites W2109571488 @default.
• W3190703354 cites W2114867964 @default.
• W3190703354 cites W2120381531 @default.
• W3190703354 cites W2125931795 @default.
• W3190703354 cites W2130768177 @default.
• W3190703354 cites W2132046883 @default.
• W3190703354 cites W2138479426 @default.
• W3190703354 cites W2141871922 @default.
• W3190703354 cites W2144181040 @default.
• W3190703354 cites W2145070313 @default.
• W3190703354 cites W2150838305 @default.
• W3190703354 cites W2154559263 @default.
• W3190703354 cites W2156914728 @default.
• W3190703354 cites W2167065392 @default.
• W3190703354 cites W2217911731 @default.
• W3190703354 cites W2302115779 @default.
• W3190703354 cites W2331082817 @default.
• W3190703354 cites W2616622214 @default.
• W3190703354 cites W2795375387 @default.
• W3190703354 cites W2922764453 @default.
• W3190703354 cites W2963791444 @default.
• W3190703354 cites W2989687490 @default.
• W3190703354 cites W4250359445 @default.
• W3190703354 cites W577479973 @default.
• W3190703354 doi "https://doi.org/10.3389/fphys.2021.708656" @default.
• W3190703354 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8371527" @default.
• W3190703354 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34421650" @default.
• W3190703354 hasPublicationYear "2021" @default.
• W3190703354 type Work @default.
• W3190703354 sameAs 3190703354 @default.
• W3190703354 citedByCount "17" @default.
• W3190703354 countsByYear W31907033542021 @default.
• W3190703354 countsByYear W31907033542022 @default.
• W3190703354 countsByYear W31907033542023 @default.
• W3190703354 crossrefType "journal-article" @default.
• W3190703354 hasAuthorship W3190703354A5018187010 @default.
• W3190703354 hasAuthorship W3190703354A5065965249 @default.
• W3190703354 hasBestOaLocation W31907033541 @default.
• W3190703354 hasConcept C126322002 @default.
• W3190703354 hasConcept C142724271 @default.
• W3190703354 hasConcept C164705383 @default.

• next