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- W3190714578 abstract "AbstractBackground Manifestations and outcomes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are not well documented in patients with common variable immunodeficiency disorder (CVID).Methods A Danish nationwide retrospective clinician-reported survey.Results Eleven patients with CVID and SARS-CoV-2 infection were identified. The median age was 50 years (range 22–72). All were on immunoglobulin replacement therapy. Eight patients had other pre-existing co-morbidities. Three patients were asymptomatic during the SARS-CoV-2 infection while seven developed mild coronavirus disease 2019 (COVID-19). One patient had more severe disease with hypoxia and required oxygen therapy. This patient had multiple co-morbidities including well known risk factors for severe COVID-19. All patients recovered.Conclusions The results suggest that CVID may not be a risk factor for severe COVID-19. However, further monitoring of this immunodeficient population is needed to confirm our observation.Keywords: COVID-19SARS-CoV-2common variable immunodeficiencyprimary immunodeficiencyinborn errors of immunity AcknowledgementsThe authors thank the patients for their involvement and willingness to participate in this study, and our colleagues at the biochemical and microbiology departments who contributed with SARS-CoV-2 antibody data. A special thanks to Nikolai Kirkby at the Department of Microbiology, Rigshospitalet, for his involvement in accessing antibody results.Disclosure statementCD: financial grants for research: Takeda; AEH: financial grants for research and a teaching salary: CSL Behring; THM is funded by a grant from The Novo Nordisk Foundation (NNF21OC0067157); TLK: advisory board member or lecturer for Bristol-Myers Squibb, GlaxoSmithKline/ViiV, Jannsen, Merck Sharp & Dohme, Gilead Sciences, Chiesi, Vertex, CSLBehring, Shire and Takeda; research grant from Gilead Sciences; has participated in immunodeficiency conferences sponsored by CSLBehring, Shire and Takeda. LDR, ODL, AM, JHL: no competing interests." @default.
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- W3190714578 date "2021-08-10" @default.
- W3190714578 modified "2023-10-18" @default.
- W3190714578 title "Low morbidity in Danish patients with common variable immunodeficiency disorder infected with severe acute respiratory syndrome coronavirus 2" @default.
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- W3190714578 doi "https://doi.org/10.1080/23744235.2021.1957144" @default.
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