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- W3190744868 abstract "Abstract Preys use their memory - where they sensed a predatory threat and whether a safe shelter is nearby - to dynamically control their survival instinct to avoid harm and reach safety. However, it remains unknown which brain regions are involved, and how such top-down control of innate behaviour is implemented at the circuit level. Here, we show that the anterior hypothalamic nucleus (AHN) is best positioned to perform this task as an exclusive target of the hippocampus (HPC) within the medial hypothalamic defense system. Selective optogenetic stimulation and inhibition of hippocampal inputs to the AHN revealed that the HPC→AHN pathway not only mediates the contextual memory of predator threats but also controls the goal-directed escape by transmitting information about the surrounding environment. These results reveal a new mechanism for experience-dependent, top-down control of innate defensive behaviours." @default.
- W3190744868 created "2021-08-16" @default.
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- W3190744868 date "2021-08-09" @default.
- W3190744868 modified "2023-09-23" @default.
- W3190744868 title "Hippocampal-hypothalamic circuit controls context-dependent innate defensive responses" @default.
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- W3190744868 doi "https://doi.org/10.1101/2021.08.06.455454" @default.
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