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• W319074543 endingPage "2843" @default.
• W319074543 startingPage "2836" @default.
• W319074543 abstract "B-chronic lymphocytic leukemia (B-CLL) is characterized by the accumulation of long-lived CD5+ B lymphocytes. We have analyzed the effect in vitro of the combination of fludarabine with cyclophosphamide and/or mitoxantrone on cells from 20 B-CLL patients. Mafosfamide, the active form of cyclophosphamide in vitro, increased the cytotoxicity of fludarabine in all of the patients studied and produced a significant synergistic effect (P &lt; .01) after 48 hours of incubation. The addition of mitoxantrone to this combination increased the cytotoxic effect in cells from 8 patients, but in the remaining 12 patients no significant increase was observed. The effect of fludarabine and mafosfamide was dose-dependent. Mafosfamide and fludarabine had a synergistic effect in inducing apoptosis of B-CLL cells as determined by DNA staining with propidium iodide and analysis of phosphatidylserine exposure. Mafosfamide significantly increased the apoptosis induced by fludarabine on CD19+ cells (P = .007), but not on CD3+ cells (P= .314). Cell viability was correlated with a decrease in Mcl-1 levels and an increase in p53 levels. These results support that fludarabine in combination with cyclophosphamide and/or mitoxantrone can be highly effective in the treatment of B-CLL." @default.
• W319074543 created "2016-06-24" @default.
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• W319074543 date "1999-10-15" @default.
• W319074543 modified "2023-10-12" @default.
• W319074543 title "In Vitro Evaluation of Fludarabine in Combination With Cyclophosphamide and/or Mitoxantrone in B-Cell Chronic Lymphocytic Leukemia" @default.
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• W319074543 doi "https://doi.org/10.1182/blood.v94.8.2836.420k35_2836_2843" @default.
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• W319074543 hasPublicationYear "1999" @default.
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