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- W3190755839 endingPage "2038" @default.
- W3190755839 startingPage "2038" @default.
- W3190755839 abstract "Allergic asthma is a chronic and heterogeneous pulmonary disease in which platelets can be activated in an IgE-mediated pathway and migrate to the airways via CCR3-dependent mechanism. Activated platelets secrete IL-33, Dkk-1, and 5-HT or overexpress CD40L on the cell surfaces to induce Type 2 immune response or interact with TSLP-stimulated myeloid DCs through the RANK-RANKL-dependent manner to tune the sensitization stage of allergic asthma. Additionally, platelets can mediate leukocyte infiltration into the lungs through P-selectin-mediated interaction with PSGL-1 and upregulate integrin expression in activated leukocytes. Platelets release myl9/12 protein to recruit CD4+CD69+ T cells to the inflammatory sites. Bronchoactive mediators, enzymes, and ROS released by platelets also contribute to the pathogenesis of allergic asthma. GM-CSF from platelets inhibits the eosinophil apoptosis, thus enhancing the chronic inflammatory response and tissue damage. Functional alterations in the mitochondria of platelets in allergic asthmatic lungs further confirm the role of platelets in the inflammation response. Given the extensive roles of platelets in allergic asthma, antiplatelet drugs have been tested in some allergic asthma patients. Therefore, elucidating the role of platelets in the pathogenesis of allergic asthma will provide us with new insights and lead to novel approaches in the treatment of this disease." @default.
- W3190755839 created "2021-08-16" @default.
- W3190755839 creator A5003590800 @default.
- W3190755839 creator A5033114800 @default.
- W3190755839 creator A5034038396 @default.
- W3190755839 creator A5036404524 @default.
- W3190755839 date "2021-08-10" @default.
- W3190755839 modified "2023-10-16" @default.
- W3190755839 title "Platelets, Not an Insignificant Player in Development of Allergic Asthma" @default.
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