FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3190784586> ?p ?o ?g. }

• W3190784586 endingPage "1420" @default.
• W3190784586 startingPage "1413" @default.
• W3190784586 abstract "Herein we report the discovery and preclinical biological evaluation of 6-(2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)-7-azaspiro[3.5]non-1-en-7-yl)-4-(trifluoromethyl)quinoline-2-carboxylic acid, compound 1 (BMS-986318), a nonbile acid farnesoid X receptor (FXR) agonist. Compound 1 exhibits potent in vitro and in vivo activation of FXR, has a suitable ADME profile, and demonstrates efficacy in the mouse bile duct ligation model of liver cholestasis and fibrosis. The overall profile of compound 1 supports its continued evaluation." @default.
• W3190784586 created "2021-08-16" @default.
• W3190784586 creator A5000187645 @default.
• W3190784586 creator A5007031430 @default.
• W3190784586 creator A5007488565 @default.
• W3190784586 creator A5018863416 @default.
• W3190784586 creator A5025403167 @default.
• W3190784586 creator A5046661488 @default.
• W3190784586 creator A5047713460 @default.
• W3190784586 creator A5052619784 @default.
• W3190784586 creator A5053488041 @default.
• W3190784586 creator A5054179990 @default.
• W3190784586 creator A5055258230 @default.
• W3190784586 creator A5067574582 @default.
• W3190784586 creator A5080949841 @default.
• W3190784586 creator A5081416815 @default.
• W3190784586 creator A5087040820 @default.
• W3190784586 creator A5089008549 @default.
• W3190784586 date "2021-08-05" @default.
• W3190784586 modified "2023-10-16" @default.
• W3190784586 title "Discovery of BMS-986318, a Potent Nonbile Acid FXR Agonist for the Treatment of Nonalcoholic Steatohepatitis" @default.
• W3190784586 cites W1964777932 @default.
• W3190784586 cites W1986688127 @default.
• W3190784586 cites W1990993250 @default.
• W3190784586 cites W2027804437 @default.
• W3190784586 cites W2041451676 @default.
• W3190784586 cites W2081218071 @default.
• W3190784586 cites W2146012023 @default.
• W3190784586 cites W2146764867 @default.
• W3190784586 cites W2171685278 @default.
• W3190784586 cites W2302011199 @default.
• W3190784586 cites W2319858193 @default.
• W3190784586 cites W2622908974 @default.
• W3190784586 cites W2769380893 @default.
• W3190784586 cites W2808733627 @default.
• W3190784586 cites W2903966071 @default.
• W3190784586 cites W2954050367 @default.
• W3190784586 cites W2982480446 @default.
• W3190784586 cites W2984973816 @default.
• W3190784586 cites W2999093388 @default.
• W3190784586 cites W2999594699 @default.
• W3190784586 cites W3033439364 @default.
• W3190784586 cites W3042315751 @default.
• W3190784586 doi "https://doi.org/10.1021/acsmedchemlett.1c00198" @default.
• W3190784586 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8436248" @default.
• W3190784586 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34531950" @default.
• W3190784586 hasPublicationYear "2021" @default.
• W3190784586 type Work @default.
• W3190784586 sameAs 3190784586 @default.
• W3190784586 citedByCount "3" @default.
• W3190784586 countsByYear W31907845862021 @default.
• W3190784586 countsByYear W31907845862022 @default.
• W3190784586 countsByYear W31907845862023 @default.
• W3190784586 crossrefType "journal-article" @default.
• W3190784586 hasAuthorship W3190784586A5000187645 @default.
• W3190784586 hasAuthorship W3190784586A5007031430 @default.
• W3190784586 hasAuthorship W3190784586A5007488565 @default.
• W3190784586 hasAuthorship W3190784586A5018863416 @default.
• W3190784586 hasAuthorship W3190784586A5025403167 @default.
• W3190784586 hasAuthorship W3190784586A5046661488 @default.
• W3190784586 hasAuthorship W3190784586A5047713460 @default.
• W3190784586 hasAuthorship W3190784586A5052619784 @default.
• W3190784586 hasAuthorship W3190784586A5053488041 @default.
• W3190784586 hasAuthorship W3190784586A5054179990 @default.
• W3190784586 hasAuthorship W3190784586A5055258230 @default.
• W3190784586 hasAuthorship W3190784586A5067574582 @default.
• W3190784586 hasAuthorship W3190784586A5080949841 @default.
• W3190784586 hasAuthorship W3190784586A5081416815 @default.
• W3190784586 hasAuthorship W3190784586A5087040820 @default.
• W3190784586 hasAuthorship W3190784586A5089008549 @default.
• W3190784586 hasBestOaLocation W31907845862 @default.
• W3190784586 hasConcept C104317684 @default.
• W3190784586 hasConcept C112705442 @default.
• W3190784586 hasConcept C126322002 @default.
• W3190784586 hasConcept C150903083 @default.
• W3190784586 hasConcept C170493617 @default.
• W3190784586 hasConcept C185592680 @default.
• W3190784586 hasConcept C203862802 @default.
• W3190784586 hasConcept C207001950 @default.
• W3190784586 hasConcept C2777067796 @default.
• W3190784586 hasConcept C2778593092 @default.
• W3190784586 hasConcept C2778938600 @default.
• W3190784586 hasConcept C2779399885 @default.
• W3190784586 hasConcept C55493867 @default.
• W3190784586 hasConcept C63932345 @default.
• W3190784586 hasConcept C69366308 @default.
• W3190784586 hasConcept C71924100 @default.
• W3190784586 hasConcept C86339819 @default.
• W3190784586 hasConcept C86803240 @default.
• W3190784586 hasConcept C98274493 @default.
• W3190784586 hasConceptScore W3190784586C104317684 @default.
• W3190784586 hasConceptScore W3190784586C112705442 @default.
• W3190784586 hasConceptScore W3190784586C126322002 @default.
• W3190784586 hasConceptScore W3190784586C150903083 @default.
• W3190784586 hasConceptScore W3190784586C170493617 @default.
• W3190784586 hasConceptScore W3190784586C185592680 @default.
• W3190784586 hasConceptScore W3190784586C203862802 @default.
• W3190784586 hasConceptScore W3190784586C207001950 @default.

• next