Matches in SemOpenAlex for { <https://semopenalex.org/work/W3190795823> ?p ?o ?g. }
- W3190795823 abstract "Toll-like receptor 2 and 4 (TLR2, TLR4) signaling is implicated in atherosclerotic plaque formation. The two-stage master regulator Virtual Inference of Protein-activity by Enriched Regulon (VIPER) analysis of macrophage TLR2 and TLR4 signature genes integrated with coexpression network genes derived from 371 patient-derived carotid specimens identifies activated RNA polymerase II transcriptional coactivator p15 (SUB1/Sub1, PC4) as a master regulon in the atherogenic TLR response. It is found that TLR2 and TLR4 signaling is proinflammatory and proatherosclerotic in chow-fed apolipoprotein E-deficient (ApoE-/- ) mice. Through transgenic myeloid-specific Sub1 knockout in ApoE-/- mice, it is discovered that these proatherosclerotic effects of TLR2 and TLR4 signaling are mediated by Sub1. Sub1 knockout in macrophages enhances anti-inflammatory M2 macrophage polarization and cholesterol efflux. Irradiated low density lipoprotein receptor-deficient (Ldlr-/- ) mice transplanted with Sub1-/- murine bone marrow display reduced atherosclerosis. Promoter analysis reveals Sub1-dependent activation of interferon regulatory factor 1 (Irf1) transcription in a casein kinase 2 (Ck2)-dependent manner, and Sub1-knockout macrophages display decreased Irf1 expression. Artificial Irf1 overexpression in Sub1-knockout macrophages enhances proinflammatory M1 skewing and lowers cholesterol clearance. In conclusion, the TLR master regulon Sub1, and its downstream effect on the transcription factor Irf1, promotes a proinflammatory M1 macrophage phenotype and enhances atherosclerotic burden in vivo." @default.
- W3190795823 created "2021-08-16" @default.
- W3190795823 creator A5008496072 @default.
- W3190795823 creator A5015551771 @default.
- W3190795823 creator A5018863416 @default.
- W3190795823 creator A5027764469 @default.
- W3190795823 creator A5028805082 @default.
- W3190795823 creator A5037689234 @default.
- W3190795823 creator A5053491673 @default.
- W3190795823 creator A5059852876 @default.
- W3190795823 creator A5063610143 @default.
- W3190795823 creator A5064429764 @default.
- W3190795823 creator A5069849278 @default.
- W3190795823 creator A5074220267 @default.
- W3190795823 creator A5074963963 @default.
- W3190795823 creator A5081086453 @default.
- W3190795823 creator A5082221539 @default.
- W3190795823 creator A5089976043 @default.
- W3190795823 creator A5090883359 @default.
- W3190795823 date "2021-08-10" @default.
- W3190795823 modified "2023-10-16" @default.
- W3190795823 title "The Transcription Factor <i>SUB1</i> Is a Master Regulator of the Macrophage TLR Response in Atherosclerosis" @default.
- W3190795823 cites W1595293335 @default.
- W3190795823 cites W1978369960 @default.
- W3190795823 cites W1982642213 @default.
- W3190795823 cites W1983619827 @default.
- W3190795823 cites W1983874326 @default.
- W3190795823 cites W1986480779 @default.
- W3190795823 cites W1988708102 @default.
- W3190795823 cites W1990512452 @default.
- W3190795823 cites W2016474243 @default.
- W3190795823 cites W2019680103 @default.
- W3190795823 cites W2031047943 @default.
- W3190795823 cites W2033883349 @default.
- W3190795823 cites W2035271418 @default.
- W3190795823 cites W2041600084 @default.
- W3190795823 cites W2047940964 @default.
- W3190795823 cites W2050040337 @default.
- W3190795823 cites W2051093466 @default.
- W3190795823 cites W2055022595 @default.
- W3190795823 cites W2055348159 @default.
- W3190795823 cites W2056241473 @default.
- W3190795823 cites W2073426547 @default.
- W3190795823 cites W2084798714 @default.
- W3190795823 cites W2085069678 @default.
- W3190795823 cites W2107665951 @default.
- W3190795823 cites W2110501180 @default.
- W3190795823 cites W2110615544 @default.
- W3190795823 cites W2113934014 @default.
- W3190795823 cites W2116634113 @default.
- W3190795823 cites W2119092533 @default.
- W3190795823 cites W2124710402 @default.
- W3190795823 cites W2142098891 @default.
- W3190795823 cites W2142248480 @default.
- W3190795823 cites W2159560463 @default.
- W3190795823 cites W2170989872 @default.
- W3190795823 cites W2198703760 @default.
- W3190795823 cites W2276012049 @default.
- W3190795823 cites W2285093314 @default.
- W3190795823 cites W2387073006 @default.
- W3190795823 cites W2472255748 @default.
- W3190795823 cites W2531292557 @default.
- W3190795823 cites W2548089119 @default.
- W3190795823 cites W2555385098 @default.
- W3190795823 cites W2581345503 @default.
- W3190795823 cites W2737694430 @default.
- W3190795823 cites W2739469145 @default.
- W3190795823 cites W2742860042 @default.
- W3190795823 cites W2764291671 @default.
- W3190795823 cites W2889211895 @default.
- W3190795823 cites W2914432347 @default.
- W3190795823 cites W2940102930 @default.
- W3190795823 cites W2977174403 @default.
- W3190795823 cites W2980955165 @default.
- W3190795823 cites W3013522609 @default.
- W3190795823 cites W3014742929 @default.
- W3190795823 cites W3105982350 @default.
- W3190795823 cites W3190795823 @default.
- W3190795823 cites W2768547330 @default.
- W3190795823 doi "https://doi.org/10.1002/advs.202004162" @default.
- W3190795823 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8498911" @default.
- W3190795823 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34378353" @default.
- W3190795823 hasPublicationYear "2021" @default.
- W3190795823 type Work @default.
- W3190795823 sameAs 3190795823 @default.
- W3190795823 citedByCount "9" @default.
- W3190795823 countsByYear W31907958232021 @default.
- W3190795823 countsByYear W31907958232022 @default.
- W3190795823 countsByYear W31907958232023 @default.
- W3190795823 crossrefType "journal-article" @default.
- W3190795823 hasAuthorship W3190795823A5008496072 @default.
- W3190795823 hasAuthorship W3190795823A5015551771 @default.
- W3190795823 hasAuthorship W3190795823A5018863416 @default.
- W3190795823 hasAuthorship W3190795823A5027764469 @default.
- W3190795823 hasAuthorship W3190795823A5028805082 @default.
- W3190795823 hasAuthorship W3190795823A5037689234 @default.
- W3190795823 hasAuthorship W3190795823A5053491673 @default.
- W3190795823 hasAuthorship W3190795823A5059852876 @default.
- W3190795823 hasAuthorship W3190795823A5063610143 @default.
- W3190795823 hasAuthorship W3190795823A5064429764 @default.