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- W3190803257 abstract "Abstract: Purpose: Oral drug delivery system has always been a preferred choice for the treatment of peptic ulcer and gastroesophageal reflux diseases. Being a proton pump inhibitor omeprazole restricts gastric acid secretion but the foremost downside is its degradation in acidic environments. The systemic absorption of gastro-unstable drugs can be improved by the enteric coating. Materials and Methods: This study was aimed at developing an effective enteric coating for omeprazole tablets using HPMC E5-LV and Hydroxypropyl Methylcellulose Acetate Succinate (HPMC-AS) polymers. The core tablets were subcoated with HPMC E5-LV which acted as a barrier between core tablet and enteric coated tablet. The enteric coating was applied using HPMC-AS. Results: Dissolution information unveiled that the enteric coat remained in place for 2 hr in acidic medium (0.1N HCl) and later dissolved when came in contact with basic media (acetate buffer pH 6.8), it dissolved within a jiffy. Conclusion: The release profile showed 91 to 98% drug release within 1hr in pH 6.8 Acetate buffer. Further instrumental analysis was performed to ascertain drug-polymer interaction. Key words: Proton pump inhibitor, Enteric coating, HPMC, Omeprazole, Dissolution enhancement." @default.
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- W3190803257 date "2021-08-16" @default.
- W3190803257 modified "2023-09-23" @default.
- W3190803257 title "Enteric Dissolution Enhancement of Engineered Gastro Resistant Omeprazole Tablets using Hydroxypropyl Methylcellulose Acetate Succinate" @default.
- W3190803257 doi "https://doi.org/10.5530/ijper.55.3.139" @default.
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