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- W3190803905 abstract "Cerebral cavernous malformation (CCM) is a cerebrovascular disease in which stacks of dilated haemorrhagic capillaries form focally in the brain. Whether and how defective mechanotransduction, cellular mosaicism and inflammation interplay to sustain the progression of CCM disease is unknown. Here, we reveal that CCM1- and CCM2-silenced endothelial cells expanded in vitro enter into senescence-associated secretory phenotype (SASP) that they use to invade the extracellular matrix and attract surrounding wild-type endothelial and immune cells. Further, we demonstrate that this SASP is driven by the cytoskeletal, molecular and transcriptomic disorders provoked by ROCK dysfunctions. By this, we propose that CCM2 and ROCK could be parts of a scaffold controlling senescence, bringing new insights into the emerging field of the control of ageing by cellular mechanics. These in vitro findings reconcile the known dysregulated traits of CCM2-deficient endothelial cells into a unique endothelial fate. Based on these in vitro results, we propose that a SASP could link the increased ROCK-dependent cell contractility in CCM2-deficient endothelial cells with microenvironment remodelling and long-range chemo-attraction of endothelial and immune cells." @default.
- W3190803905 created "2021-08-16" @default.
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- W3190803905 date "2021-08-03" @default.
- W3190803905 modified "2023-09-27" @default.
- W3190803905 title "CCM2-deficient endothelial cells undergo a ROCK-dependent reprogramming into senescence-associated secretory phenotype" @default.
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- W3190803905 cites W1964707962 @default.
- W3190803905 cites W1966101847 @default.
- W3190803905 cites W1966645907 @default.
- W3190803905 cites W1991356125 @default.
- W3190803905 cites W2004220217 @default.
- W3190803905 cites W2008065145 @default.
- W3190803905 cites W2018818236 @default.
- W3190803905 cites W2023388112 @default.
- W3190803905 cites W2027052842 @default.
- W3190803905 cites W2027272443 @default.
- W3190803905 cites W2031244119 @default.
- W3190803905 cites W2031434429 @default.
- W3190803905 cites W2043270774 @default.
- W3190803905 cites W2058599028 @default.
- W3190803905 cites W2064760277 @default.
- W3190803905 cites W2073235331 @default.
- W3190803905 cites W2074214268 @default.
- W3190803905 cites W2084806891 @default.
- W3190803905 cites W2095035711 @default.
- W3190803905 cites W2098414653 @default.
- W3190803905 cites W2099043491 @default.
- W3190803905 cites W2099824652 @default.
- W3190803905 cites W2110537012 @default.
- W3190803905 cites W2115034875 @default.
- W3190803905 cites W2115852450 @default.
- W3190803905 cites W2117038928 @default.
- W3190803905 cites W2122244785 @default.
- W3190803905 cites W2123892536 @default.
- W3190803905 cites W2130410032 @default.
- W3190803905 cites W2142694254 @default.
- W3190803905 cites W2147030667 @default.
- W3190803905 cites W2147327763 @default.
- W3190803905 cites W2147919276 @default.
- W3190803905 cites W2150748567 @default.
- W3190803905 cites W2171538469 @default.
- W3190803905 cites W2175209522 @default.
- W3190803905 cites W2179438025 @default.
- W3190803905 cites W2222502154 @default.
- W3190803905 cites W2278220345 @default.
- W3190803905 cites W2333129081 @default.
- W3190803905 cites W2397706209 @default.
- W3190803905 cites W2507961570 @default.
- W3190803905 cites W2555936050 @default.
- W3190803905 cites W2560115947 @default.
- W3190803905 cites W2568864972 @default.
- W3190803905 cites W2612222797 @default.
- W3190803905 cites W2729014275 @default.
- W3190803905 cites W2749511637 @default.
- W3190803905 cites W2800217088 @default.
- W3190803905 cites W2884072849 @default.
- W3190803905 cites W2900396431 @default.
- W3190803905 cites W2903255406 @default.
- W3190803905 cites W2911642321 @default.
- W3190803905 cites W2916599339 @default.
- W3190803905 cites W2918572759 @default.
- W3190803905 cites W2950985970 @default.
- W3190803905 cites W2951067314 @default.
- W3190803905 cites W2954376097 @default.
- W3190803905 cites W2954445592 @default.
- W3190803905 cites W2954600468 @default.
- W3190803905 cites W2954759368 @default.
- W3190803905 cites W2966267271 @default.
- W3190803905 cites W2969361259 @default.
- W3190803905 cites W2977336849 @default.
- W3190803905 cites W2989817090 @default.
- W3190803905 cites W2995847397 @default.
- W3190803905 cites W2999559738 @default.
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- W3190803905 cites W3036380645 @default.
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- W3190803905 doi "https://doi.org/10.1007/s10456-021-09809-2" @default.
- W3190803905 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34342749" @default.
- W3190803905 hasPublicationYear "2021" @default.
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