FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3190900954> ?p ?o ?g. }

• W3190900954 abstract "Microvascular obstruction is a common repercussion of percutaneous coronary intervention in treating acute myocardial infarction, and results from a combination of downstream microembolization, ischemia-reperfusion injury, and inflammation. Ultrasound-targeted microbubble cavitation (UTMC) uses external therapeutic ultrasound pulsation to target intravascularly infused microbubble contrast agents to produce shear stresses which mechanically disrupt obstructing microemboli. This work aims to enhance the therapeutic effects of UTMC through synergistic co-administration of nitrite for enhancement of perfusion and nitric oxide bioavailability (Aim 1) and development of a novel microbubble agent using nitro-alkenes for therapeutic reduction of inflammation after ischemia-reperfusion injury (Aim 2).For characterization and optimization of nitrite co-therapy with UTMC, a rat gastrocnemius model was used with contrast-enhanced ultrasound imaging. A nitric oxide porphyrinic membrane catheter probe was inserted into the treatment site for real-time measurement of nitric oxide concentration changes. In addition to nitrite co-therapy, effects of administering an endothelial nitric oxide synthase inhibitor as well as varying microbubble concentration and therapeutic ultrasound pressure were studied. Results showed that UTMC and nitrite demonstrated positive synergy for enhancing nitric oxide concentration and perfusion which depended on functional endothelial nitric oxide synthase.After a novel nitro-alkene microbubble agent was synthesized and characterized, it was applied in both healthy and ischemia-reperfusion injury rat gastrocnemius models. Tissue samples were collected after treatment for quantification of nitro-alkene delivery, changes in inflammatory gene expression, and contrast-enhanced ultrasound imaging was used to quantify changes in hindlimb perfusion after treatment. Results showed that incorporation of the nitro-alkene into a microbubble formulation with UTMC greatly enhanced targeted tissue delivery of the nitro-alkene compared to co-infusion with standard microbubbles and systemic infusion alone. In addition, nitro-alkene microbubble UTMC resulted in greatly enhanced perfusion as well as decreases in inflammatory gene expression.In all, both of these applications of enhancing UTMC therapy demonstrate significant mechanistic interactions with endogenous nitric oxide metabolism and may serve to enhance nitric oxide bioavailability through different pathways. They may also improve the relevance of UTMC in treating the biological sequelae of microvascular obstruction without compromising its mechanical function in disrupting microemboli." @default.
• W3190900954 created "2021-08-16" @default.
• W3190900954 creator A5016815495 @default.
• W3190900954 date "2020-08-03" @default.
• W3190900954 modified "2023-09-26" @default.
• W3190900954 title "Applications of Ultrasound-targeted Microbubble Cavitation with Sodium Nitrite and Nitro-alkenes" @default.
• W3190900954 hasPublicationYear "2020" @default.
• W3190900954 type Work @default.
• W3190900954 sameAs 3190900954 @default.
• W3190900954 citedByCount "0" @default.
• W3190900954 crossrefType "journal-article" @default.
• W3190900954 hasAuthorship W3190900954A5016815495 @default.
• W3190900954 hasConcept C126322002 @default.
• W3190900954 hasConcept C146957229 @default.
• W3190900954 hasConcept C164705383 @default.
• W3190900954 hasConcept C185592680 @default.
• W3190900954 hasConcept C2777622882 @default.
• W3190900954 hasConcept C519581460 @default.
• W3190900954 hasConcept C541997718 @default.
• W3190900954 hasConcept C71924100 @default.
• W3190900954 hasConcept C98274493 @default.
• W3190900954 hasConceptScore W3190900954C126322002 @default.
• W3190900954 hasConceptScore W3190900954C146957229 @default.
• W3190900954 hasConceptScore W3190900954C164705383 @default.
• W3190900954 hasConceptScore W3190900954C185592680 @default.
• W3190900954 hasConceptScore W3190900954C2777622882 @default.
• W3190900954 hasConceptScore W3190900954C519581460 @default.
• W3190900954 hasConceptScore W3190900954C541997718 @default.
• W3190900954 hasConceptScore W3190900954C71924100 @default.
• W3190900954 hasConceptScore W3190900954C98274493 @default.
• W3190900954 hasLocation W31909009541 @default.
• W3190900954 hasOpenAccess W3190900954 @default.
• W3190900954 hasPrimaryLocation W31909009541 @default.
• W3190900954 hasRelatedWork W1977579236 @default.
• W3190900954 hasRelatedWork W1981643757 @default.
• W3190900954 hasRelatedWork W2003231813 @default.
• W3190900954 hasRelatedWork W2014325729 @default.
• W3190900954 hasRelatedWork W2014848058 @default.
• W3190900954 hasRelatedWork W2025197569 @default.
• W3190900954 hasRelatedWork W2064608191 @default.
• W3190900954 hasRelatedWork W2122199958 @default.
• W3190900954 hasRelatedWork W2142129201 @default.
• W3190900954 hasRelatedWork W2161338486 @default.
• W3190900954 hasRelatedWork W2170804352 @default.
• W3190900954 hasRelatedWork W2172230065 @default.
• W3190900954 hasRelatedWork W2329443734 @default.
• W3190900954 hasRelatedWork W2378183065 @default.
• W3190900954 hasRelatedWork W2587539143 @default.
• W3190900954 hasRelatedWork W2593658709 @default.
• W3190900954 hasRelatedWork W2992984510 @default.
• W3190900954 hasRelatedWork W31148468 @default.
• W3190900954 hasRelatedWork W3125730142 @default.
• W3190900954 hasRelatedWork W36675008 @default.
• W3190900954 isParatext "false" @default.
• W3190900954 isRetracted "false" @default.
• W3190900954 magId "3190900954" @default.
• W3190900954 workType "article" @default.