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- W3190904371 abstract "Abstract Objectives To study the effect of Zingiber officinale and Hibiscus sabdariffa on pharmacokinetics and pharmacodynamics of amlodipine. Methods Hypertension was induced in rats (SBP 173.2 ± 1.7 mmHg, mean, 1–24 h). Systolic blood pressure (SBP), diastolic blood pressure (DBP), mean blood pressure (MBP) and heart rate (HR) of group-I (amlodipine treated), group-II (Z. officinale, and Z. officinale + amlodipine) and group-III (H. sabdariffa, and H. sabdariffa + amlodipine) animals were measured by “tail-cuff system”. Pharmacokinetics of amlodipine with and without herbs (Z. officinale or H. sabdariffa) was also investigated. Results Z. officinale as well as H. sabdariffa decreased the SBP, DBP and MBP. Concurrent treatment with Z. officinale + amlodipine (SBP 129.4 ± 4.5) or H. sabdariffa + amlodipine (SBP 130.4 ± 3.9) showed higher decrease in BP (mean, 1–24h), than individually administered amlodipine (SBP 149.5 ± 2.4) or Z. officinale (SBP 150.2 ± 3.1) or H. sabdariffa (SBP 139.1 ± 1.2). These herbs also influenced the Cmax, AUC0-t, and Tmax of amlodipine. H. sabdariffa increased AUC0-t of amlodipine from 81.8 ± 14.7 to 125.0 ± 10.6 (ng h/mL). Conclusion Simultaneous administration of Z. officinale or H. sabdariffa with amlodipine, improves its pharmacodynamic response." @default.
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- W3190904371 date "2021-08-10" @default.
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- W3190904371 title "Effect of <i>Hibiscus sabdariffa</i> and <i>Zingiber officinale</i> on pharmacokinetics and pharmacodynamics of amlodipine" @default.
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- W3190904371 doi "https://doi.org/10.1093/jpp/rgaa062" @default.
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