Matches in SemOpenAlex for { <https://semopenalex.org/work/W3190967209> ?p ?o ?g. }
- W3190967209 endingPage "e043860" @default.
- W3190967209 startingPage "e043860" @default.
- W3190967209 abstract "Objective Asthma often coexists with gastro-oesophageal reflux disease (GERD). The effect of proton pump inhibitors (PPIs) treatment on asthma concomitant with GERD was inconsistent. This study aimed to assess whether PPIs treatment improved morning peak expiratory flow (mPEF) in asthma patients with GERD. Data sources PubMed, MEDLINE, EMBASE, Web of Science, Cochrane Library and ClinicalTrials.gov; hand searching for reference lists; contacted with authors if necessary. Study selection All eligible trials were randomised clinical trials comparing PPIs with placebo in asthma patients accompanying with GERD. Results Fourteen randomised clinical trials (2182 participants) were included. Overall, PPIs versus placebo did not affect mPEF in patients with asthma having GERD (weighted mean difference 8.68 L/min, 95% CI −2.02 to 19.37, p=0.11). Trial sequential analysis (TSA) further confirmed this finding (TSA adjusted 95% CI −1.03 to 22.25). Subgroups analyses based on the percentage of patients with symptomatic GERD≥95%, treatment duration >12 weeks also found no statistically significant benefit on mPEF. Similarly, analyses of secondary outcomes (evening PEF, forced expiratory volume in 1 s, asthma symptoms score, asthma quality of life score and episodes of asthma exacerbation) did not show significant difference between PPIs and placebo. Conclusion In this meta-analysis, PPIs therapy did not show a statistically significant improvement on mPEF in asthma patients having GERD, neither in subgroup with symptomatic GERD nor in subgroup with treatment duration >12 weeks. This analysis does not support a recommendation for PPIs therapy as empirical treatment in asthma patients with GERD. PROSPERO registration number CRD42020177330." @default.
- W3190967209 created "2021-08-16" @default.
- W3190967209 creator A5003837657 @default.
- W3190967209 creator A5007785866 @default.
- W3190967209 creator A5015134642 @default.
- W3190967209 creator A5077597404 @default.
- W3190967209 date "2021-08-01" @default.
- W3190967209 modified "2023-10-01" @default.
- W3190967209 title "Randomised trials of proton pump inhibitors for gastro-oesophageal reflux disease in patients with asthma: an updated systematic review and meta-analysis" @default.
- W3190967209 cites W1504117939 @default.
- W3190967209 cites W1921328304 @default.
- W3190967209 cites W1967396226 @default.
- W3190967209 cites W1987320117 @default.
- W3190967209 cites W2011452201 @default.
- W3190967209 cites W2034967838 @default.
- W3190967209 cites W2040391660 @default.
- W3190967209 cites W2045344852 @default.
- W3190967209 cites W2048914638 @default.
- W3190967209 cites W2057239514 @default.
- W3190967209 cites W2061556752 @default.
- W3190967209 cites W2062334331 @default.
- W3190967209 cites W2064534430 @default.
- W3190967209 cites W2073063770 @default.
- W3190967209 cites W2078323130 @default.
- W3190967209 cites W2084916357 @default.
- W3190967209 cites W2090796069 @default.
- W3190967209 cites W2098923148 @default.
- W3190967209 cites W2109215965 @default.
- W3190967209 cites W2114442699 @default.
- W3190967209 cites W2116971992 @default.
- W3190967209 cites W2133962040 @default.
- W3190967209 cites W2140036464 @default.
- W3190967209 cites W2150389246 @default.
- W3190967209 cites W2159660788 @default.
- W3190967209 cites W2171603695 @default.
- W3190967209 cites W2184017757 @default.
- W3190967209 cites W2601675613 @default.
- W3190967209 cites W2744685332 @default.
- W3190967209 cites W2768359854 @default.
- W3190967209 cites W2908896005 @default.
- W3190967209 cites W2921347520 @default.
- W3190967209 cites W3007992024 @default.
- W3190967209 cites W4237343373 @default.
- W3190967209 doi "https://doi.org/10.1136/bmjopen-2020-043860" @default.
- W3190967209 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8356177" @default.
- W3190967209 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34376437" @default.
- W3190967209 hasPublicationYear "2021" @default.
- W3190967209 type Work @default.
- W3190967209 sameAs 3190967209 @default.
- W3190967209 citedByCount "10" @default.
- W3190967209 countsByYear W31909672092022 @default.
- W3190967209 countsByYear W31909672092023 @default.
- W3190967209 crossrefType "journal-article" @default.
- W3190967209 hasAuthorship W3190967209A5003837657 @default.
- W3190967209 hasAuthorship W3190967209A5007785866 @default.
- W3190967209 hasAuthorship W3190967209A5015134642 @default.
- W3190967209 hasAuthorship W3190967209A5077597404 @default.
- W3190967209 hasBestOaLocation W31909672091 @default.
- W3190967209 hasConcept C126322002 @default.
- W3190967209 hasConcept C142724271 @default.
- W3190967209 hasConcept C168563851 @default.
- W3190967209 hasConcept C187960798 @default.
- W3190967209 hasConcept C204787440 @default.
- W3190967209 hasConcept C27081682 @default.
- W3190967209 hasConcept C2776042228 @default.
- W3190967209 hasConcept C2776478404 @default.
- W3190967209 hasConcept C2777014526 @default.
- W3190967209 hasConcept C2777014857 @default.
- W3190967209 hasConcept C2779134260 @default.
- W3190967209 hasConcept C2781025758 @default.
- W3190967209 hasConcept C43270747 @default.
- W3190967209 hasConcept C535046627 @default.
- W3190967209 hasConcept C71924100 @default.
- W3190967209 hasConcept C95190672 @default.
- W3190967209 hasConceptScore W3190967209C126322002 @default.
- W3190967209 hasConceptScore W3190967209C142724271 @default.
- W3190967209 hasConceptScore W3190967209C168563851 @default.
- W3190967209 hasConceptScore W3190967209C187960798 @default.
- W3190967209 hasConceptScore W3190967209C204787440 @default.
- W3190967209 hasConceptScore W3190967209C27081682 @default.
- W3190967209 hasConceptScore W3190967209C2776042228 @default.
- W3190967209 hasConceptScore W3190967209C2776478404 @default.
- W3190967209 hasConceptScore W3190967209C2777014526 @default.
- W3190967209 hasConceptScore W3190967209C2777014857 @default.
- W3190967209 hasConceptScore W3190967209C2779134260 @default.
- W3190967209 hasConceptScore W3190967209C2781025758 @default.
- W3190967209 hasConceptScore W3190967209C43270747 @default.
- W3190967209 hasConceptScore W3190967209C535046627 @default.
- W3190967209 hasConceptScore W3190967209C71924100 @default.
- W3190967209 hasConceptScore W3190967209C95190672 @default.
- W3190967209 hasFunder F4320321001 @default.
- W3190967209 hasIssue "8" @default.
- W3190967209 hasLocation W31909672091 @default.
- W3190967209 hasLocation W31909672092 @default.
- W3190967209 hasOpenAccess W3190967209 @default.
- W3190967209 hasPrimaryLocation W31909672091 @default.
- W3190967209 hasRelatedWork W2343507876 @default.
- W3190967209 hasRelatedWork W2772654920 @default.