FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3190968727> ?p ?o ?g. }

• W3190968727 endingPage "102097" @default.
• W3190968727 startingPage "102097" @default.
• W3190968727 abstract "Lipid nitroalkenes - nitro-fatty acids (NO2-FAs) are formed in vivo via the interaction of reactive nitrogen species with unsaturated fatty acids. The resulting electrophilic NO2-FAs play an important role in redox homeostasis and cellular stress response. This study investigated the physicochemical properties and reactivity of two NO2-FAs: 9/10-nitrooleic acid (1) and its newly prepared 1-monoacyl ester, (E)-2,3-hydroxypropyl 9/10-nitrooctadec-9-enoate (2), both synthesized by a direct radical nitration approach. Compounds 1 and 2 were investigated in an aqueous medium and after incorporation into lipid nanoparticles prepared from 1-monoolein, cubosomes 1@CUB and 2@CUB. Using an electrochemical analysis and LC-MS, free 1 and 2 were found to be unstable under acidic conditions, and their degradation occurred in an aqueous environment within a few minutes or hours. This degradation was associated with the production of the NO radical, as confirmed by fluorescence assay. In contrast, preparations 1@CUB and 2@CUB exhibited a significant increase in the stability of the loaded 1 and 2 up to several days to weeks. In addition to experimental data, density functional theory-based calculation results on the electronic structure and structural variability (open and closed configuration) of 1 and 2 were obtained. Finally, experiments with a human HaCaT keratinocyte cell line demonstrated the ability of 1@CUB and 2@CUB to penetrate through the cytoplasmic membrane and modulate cellular pathways, which was exemplified by the Keap1 protein level monitoring. Free 1 and 2 and the cubosomes prepared from them showed cytotoxic effect on HaCaT cells with IC50 values ranging from 1 to 8 μM after 24 h. The further development of cubosomal preparations with embedded electrophilic NO2-FAs may not only contribute to the field of fundamental research, but also to their application using an optimized lipid delivery vehicle." @default.
• W3190968727 created "2021-08-16" @default.
• W3190968727 creator A5001527433 @default.
• W3190968727 creator A5004097152 @default.
• W3190968727 creator A5004826274 @default.
• W3190968727 creator A5013239806 @default.
• W3190968727 creator A5013532547 @default.
• W3190968727 creator A5014998393 @default.
• W3190968727 creator A5023090583 @default.
• W3190968727 creator A5045688722 @default.
• W3190968727 creator A5050426890 @default.
• W3190968727 creator A5057573236 @default.
• W3190968727 creator A5069066705 @default.
• W3190968727 creator A5070176604 @default.
• W3190968727 date "2021-10-01" @default.
• W3190968727 modified "2023-09-30" @default.
• W3190968727 title "Cubosomal lipid formulation of nitroalkene fatty acids: Preparation, stability and biological effects" @default.
• W3190968727 cites W1964417520 @default.
• W3190968727 cites W1976415753 @default.
• W3190968727 cites W1982380290 @default.
• W3190968727 cites W1991345823 @default.
• W3190968727 cites W1993635466 @default.
• W3190968727 cites W1998981380 @default.
• W3190968727 cites W2005335340 @default.
• W3190968727 cites W2013365951 @default.
• W3190968727 cites W2016532893 @default.
• W3190968727 cites W2027782349 @default.
• W3190968727 cites W2029961407 @default.
• W3190968727 cites W2031801552 @default.
• W3190968727 cites W2032286544 @default.
• W3190968727 cites W2037504650 @default.
• W3190968727 cites W2049890028 @default.
• W3190968727 cites W2051116806 @default.
• W3190968727 cites W2052524240 @default.
• W3190968727 cites W2056713365 @default.
• W3190968727 cites W2083098515 @default.
• W3190968727 cites W2089051730 @default.
• W3190968727 cites W2106452970 @default.
• W3190968727 cites W2109621677 @default.
• W3190968727 cites W2120807382 @default.
• W3190968727 cites W2128803340 @default.
• W3190968727 cites W2143723050 @default.
• W3190968727 cites W2154933226 @default.
• W3190968727 cites W2202703189 @default.
• W3190968727 cites W2267902799 @default.
• W3190968727 cites W2483469289 @default.
• W3190968727 cites W2518085003 @default.
• W3190968727 cites W2528806584 @default.
• W3190968727 cites W2557798862 @default.
• W3190968727 cites W2560836594 @default.
• W3190968727 cites W2563138690 @default.
• W3190968727 cites W2564419925 @default.
• W3190968727 cites W2606806481 @default.
• W3190968727 cites W2616469873 @default.
• W3190968727 cites W2767245590 @default.
• W3190968727 cites W2794075623 @default.
• W3190968727 cites W2794389343 @default.
• W3190968727 cites W2795453453 @default.
• W3190968727 cites W2799615157 @default.
• W3190968727 cites W2808722599 @default.
• W3190968727 cites W2811163292 @default.
• W3190968727 cites W2861107650 @default.
• W3190968727 cites W2901778245 @default.
• W3190968727 cites W2941666579 @default.
• W3190968727 cites W2944359626 @default.
• W3190968727 cites W2950594181 @default.
• W3190968727 cites W3072059081 @default.
• W3190968727 cites W3091820348 @default.
• W3190968727 cites W3130816526 @default.
• W3190968727 cites W3158972137 @default.
• W3190968727 doi "https://doi.org/10.1016/j.redox.2021.102097" @default.
• W3190968727 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8385161" @default.
• W3190968727 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34418599" @default.
• W3190968727 hasPublicationYear "2021" @default.
• W3190968727 type Work @default.
• W3190968727 sameAs 3190968727 @default.
• W3190968727 citedByCount "5" @default.
• W3190968727 countsByYear W31909687272022 @default.
• W3190968727 countsByYear W31909687272023 @default.
• W3190968727 crossrefType "journal-article" @default.
• W3190968727 hasAuthorship W3190968727A5001527433 @default.
• W3190968727 hasAuthorship W3190968727A5004097152 @default.
• W3190968727 hasAuthorship W3190968727A5004826274 @default.
• W3190968727 hasAuthorship W3190968727A5013239806 @default.
• W3190968727 hasAuthorship W3190968727A5013532547 @default.
• W3190968727 hasAuthorship W3190968727A5014998393 @default.
• W3190968727 hasAuthorship W3190968727A5023090583 @default.
• W3190968727 hasAuthorship W3190968727A5045688722 @default.
• W3190968727 hasAuthorship W3190968727A5050426890 @default.
• W3190968727 hasAuthorship W3190968727A5057573236 @default.
• W3190968727 hasAuthorship W3190968727A5069066705 @default.
• W3190968727 hasAuthorship W3190968727A5070176604 @default.
• W3190968727 hasBestOaLocation W31909687271 @default.
• W3190968727 hasConcept C118995209 @default.
• W3190968727 hasConcept C12554922 @default.
• W3190968727 hasConcept C150903083 @default.
• W3190968727 hasConcept C185592680 @default.
• W3190968727 hasConcept C202751555 @default.

• next