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- W3191036774 abstract "Enterococci are Gram-positive bacteria that have evolved to thrive as both commensals and pathogens, largely due to their accumulation of mobile genetic elements via horizontal gene transfer (HGT). Common agents of HGT include plasmids, transposable elements, and temperate bacteriophages. These vehicles of HGT have facilitated the evolution of the enterococci, specifically Enterococcus faecalis and Enterococcus faecium, into multidrug-resistant hospital-acquired pathogens. On the other hand, commensal strains of Enterococcus harbor CRISPR-Cas systems that prevent the acquisition of foreign DNA, restricting the accumulation of mobile genetic elements. In this review, we discuss enterococcal mobile genetic elements by highlighting their contributions to bacterial fitness, examine the impact of CRISPR-Cas on their acquisition, and identify key areas of research that can improve our understanding of enterococcal evolution and ecology." @default.
- W3191036774 created "2021-08-16" @default.
- W3191036774 creator A5012445165 @default.
- W3191036774 creator A5044971128 @default.
- W3191036774 creator A5070783453 @default.
- W3191036774 creator A5080960288 @default.
- W3191036774 date "2021-10-12" @default.
- W3191036774 modified "2023-09-24" @default.
- W3191036774 title "Let Me Upgrade You: Impact of Mobile Genetic Elements on Enterococcal Adaptation and Evolution" @default.
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