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- W3191101632 abstract "In this study, we aimed to investigate the influence of N-acetylcysteine (NAC) on the gene expression profile, neoangiogenesis, neutrophils and macrophages in a rat model of incisional wounds. Before creating wounds on the backs of 24 Sprague–Dawley rats, intradermal injections were made. Lidocaine–epinephrin solutions were supplemented with 0.015%, 0.03% or 0.045% solutions of NAC, or nothing (control group). Scars were harvested on the 3rd, 7th, 14th and 60th day post-surgery. We performed immunohistochemical staining in order to visualize macrophages (anti-CD68), neutrophils (anti-MPO) and newly formed blood vessels (anti-CD31). Additionally, RT-qPCR was used to measure the relative expression of 88 genes involved in the wound healing process. On the 14th day, the number of cells stained with anti-CD68 and anti-CD31 antibodies was significantly larger in the tissues treated with 0.03% NAC compared with the control. Among the selected genes, 52 were upregulated and six were downregulated at different time points. Interestingly, NAC exerted a significant effect on the expression of 45 genes 60 days after its administration. In summation, a 0.03% NAC addition to the pre-incisional anesthetic solution improves neovasculature and increases the macrophages’ concentration at the wound site on the 14th day, as well as altering the expression of numerous genes that are responsible for the regenerative processes." @default.
- W3191101632 created "2021-08-16" @default.
- W3191101632 creator A5014694190 @default.
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- W3191101632 creator A5090724733 @default.
- W3191101632 date "2021-08-12" @default.
- W3191101632 modified "2023-09-23" @default.
- W3191101632 title "Single Dose of N-Acetylcysteine in Local Anesthesia Increases Expression of HIF1α, MAPK1, TGFβ1 and Growth Factors in Rat Wound Healing" @default.
- W3191101632 cites W1547041557 @default.
- W3191101632 cites W1571210770 @default.
- W3191101632 cites W1586173247 @default.
- W3191101632 cites W1586551928 @default.
- W3191101632 cites W1835561921 @default.
- W3191101632 cites W1906108187 @default.
- W3191101632 cites W1911021731 @default.
- W3191101632 cites W1949832432 @default.
- W3191101632 cites W1970516412 @default.
- W3191101632 cites W1971364302 @default.
- W3191101632 cites W1977289462 @default.
- W3191101632 cites W1979745959 @default.
- W3191101632 cites W1984777209 @default.
- W3191101632 cites W1986014993 @default.
- W3191101632 cites W1989762720 @default.
- W3191101632 cites W1992623478 @default.
- W3191101632 cites W1994258865 @default.
- W3191101632 cites W1997830990 @default.
- W3191101632 cites W2001760269 @default.
- W3191101632 cites W2001821041 @default.
- W3191101632 cites W2007383996 @default.
- W3191101632 cites W2009929357 @default.
- W3191101632 cites W2011809766 @default.
- W3191101632 cites W2013322971 @default.
- W3191101632 cites W2019347906 @default.
- W3191101632 cites W2021030655 @default.
- W3191101632 cites W2022110569 @default.
- W3191101632 cites W2024074049 @default.
- W3191101632 cites W2025377207 @default.
- W3191101632 cites W2030562975 @default.
- W3191101632 cites W2030828007 @default.
- W3191101632 cites W2033223516 @default.
- W3191101632 cites W2035803093 @default.
- W3191101632 cites W2037618281 @default.
- W3191101632 cites W2038097126 @default.
- W3191101632 cites W2038818854 @default.
- W3191101632 cites W2041591721 @default.
- W3191101632 cites W2042811173 @default.
- W3191101632 cites W2045850003 @default.
- W3191101632 cites W2049634330 @default.
- W3191101632 cites W2051421411 @default.
- W3191101632 cites W2060221269 @default.
- W3191101632 cites W2060528025 @default.
- W3191101632 cites W2061992885 @default.
- W3191101632 cites W2062177658 @default.
- W3191101632 cites W2062336866 @default.
- W3191101632 cites W2063076489 @default.
- W3191101632 cites W2063695842 @default.
- W3191101632 cites W2068440683 @default.
- W3191101632 cites W2074883153 @default.
- W3191101632 cites W2075194339 @default.
- W3191101632 cites W2079639967 @default.
- W3191101632 cites W2087044587 @default.
- W3191101632 cites W2089681783 @default.
- W3191101632 cites W2093501881 @default.
- W3191101632 cites W2101546624 @default.
- W3191101632 cites W2102010912 @default.
- W3191101632 cites W2102815431 @default.
- W3191101632 cites W2104748529 @default.
- W3191101632 cites W2114644968 @default.
- W3191101632 cites W2117269334 @default.
- W3191101632 cites W2119778962 @default.
- W3191101632 cites W2127479170 @default.
- W3191101632 cites W2127938351 @default.
- W3191101632 cites W2128692903 @default.
- W3191101632 cites W2132075120 @default.
- W3191101632 cites W2135365602 @default.
- W3191101632 cites W2137173748 @default.
- W3191101632 cites W2139466694 @default.
- W3191101632 cites W2141676073 @default.
- W3191101632 cites W2148356659 @default.
- W3191101632 cites W2152898182 @default.
- W3191101632 cites W2159152499 @default.
- W3191101632 cites W2163809998 @default.
- W3191101632 cites W2164481653 @default.
- W3191101632 cites W2165178639 @default.
- W3191101632 cites W2165700649 @default.
- W3191101632 cites W2171118123 @default.
- W3191101632 cites W2172693840 @default.
- W3191101632 cites W2220643393 @default.
- W3191101632 cites W2293662776 @default.
- W3191101632 cites W2399316652 @default.