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- W3191133356 abstract "Abstract Human centromeric chromatin is assembled from CENP-A nucleosomes 1 and repetitive α-satellite DNA sequences 2 and provides a foundation for kinetochore assembly in mitosis. Biophysical experiments led to a hypothesis that the repetitive DNA sequences form a highly folded chromatin scaffold necessary for function, but this idea was revised when fully functional evolutionary new centromeres (ENCs) or neocentromeres were found to form on non-repetitive DNA. To understand if centromeres have a special chromatin structure we have genetically isolated a single human chromosome harbouring a neocentromere and investigated its organisation. The centromere core is enriched in RNA pol II, active epigenetic marks and remodelled by transcription to form a negatively supercoiled ‘open’ chromatin domain. In contrast, centromerisation causes a spreading of repressive epigenetic marks to flanking regions, delimited by H3K27me3 polycomb boundaries and divergent genes. The flanking domain is partially remodelled to form ‘compact’ chromatin, with characteristics similar to satellite-containing pericentromeric chromatin, but exhibits low level genomic instability. We provide a model for centromere chromatin structure and suggest that open chromatin provides a foundation for a stable kinetochore whilst pericentromeric heterochromatin generates surrounding mechanical rigidity." @default.
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- W3191133356 date "2021-08-02" @default.
- W3191133356 modified "2023-09-23" @default.
- W3191133356 title "Centromere formation remodels chromatin fibre structure" @default.
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- W3191133356 doi "https://doi.org/10.1101/2021.08.01.454615" @default.
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