Matches in SemOpenAlex for { <https://semopenalex.org/work/W3191215618> ?p ?o ?g. }
- W3191215618 endingPage "30" @default.
- W3191215618 startingPage "9" @default.
- W3191215618 abstract "The study aimed to screen mutation of human homeostatic iron regulator (HFE) in colorectal carcinoma (CRC) and detect their associations with clinicopathological parameters. Expression of HFE was determined by quantitative polymerase chain reaction in matched CRC and non neoplastic colorectal mucosal tissue of 76 patients. Genomic DNA extracted were subjected to high high-resolution melt curve analysis and Sanger sequencing to detect mutations in HFE. The associations of the identified mutations with a variety of clinical features were determined. Approximately 60% of CRC showed low HFE expression. Of the ten 10 mutations identified in exons 2 and 4, c.187C>G (H63D), c845G>A (C282Y), c.193A>T (S65C), g.3828T>C, g.5795T>C, and g.5728G>A were known mutations. Four novel mutations were discovered; : c.184G>A, c.220T>G, c.322A>C, and c.324T>C. Heterozygous H63D and C282Y mutations were seen in 71% and 49% of cancer tissue, respectively. Tumour site (p = 0.048) and gender (p = 0.039) were significantly associated with H63D and C282Y mutation status, respectively. Local spread of cancer was significantly associated with C282Y mutations in CRC cancer and adjacent non-neoplastic tissue (p = 0.029 & and p = 0.004, respectively). There was a statistically significant association between H63D and C282Y negativity in matched non-neoplastic colorectal mucosa tissue and pathological staging of cancer (p = 0.047 & and p = 0.001, respectively). Patients with H63D and C282Y mutations in cancer tissue tend to have higher survival rates. Hence HFE mutations are common in CRC and are associated with clinicopathological parameters, implying the potential clinical significance of HFE mutations in colorectal carcinogenesis." @default.
- W3191215618 created "2021-08-16" @default.
- W3191215618 creator A5003055755 @default.
- W3191215618 creator A5018228791 @default.
- W3191215618 creator A5035371015 @default.
- W3191215618 creator A5051254921 @default.
- W3191215618 creator A5057612848 @default.
- W3191215618 creator A5065237325 @default.
- W3191215618 creator A5070001516 @default.
- W3191215618 creator A5083962017 @default.
- W3191215618 creator A5085659906 @default.
- W3191215618 date "2021-11-01" @default.
- W3191215618 modified "2023-10-14" @default.
- W3191215618 title "HFE variants in colorectal cancer and their clinicopathological correlations" @default.
- W3191215618 cites W1841354258 @default.
- W3191215618 cites W1876131599 @default.
- W3191215618 cites W1970413157 @default.
- W3191215618 cites W1986604538 @default.
- W3191215618 cites W2005600431 @default.
- W3191215618 cites W2042572788 @default.
- W3191215618 cites W2052218554 @default.
- W3191215618 cites W2082390213 @default.
- W3191215618 cites W2086525307 @default.
- W3191215618 cites W2099792886 @default.
- W3191215618 cites W2107277218 @default.
- W3191215618 cites W2116858428 @default.
- W3191215618 cites W2127186663 @default.
- W3191215618 cites W2142644783 @default.
- W3191215618 cites W2144085011 @default.
- W3191215618 cites W2149406240 @default.
- W3191215618 cites W2153913749 @default.
- W3191215618 cites W2162098634 @default.
- W3191215618 cites W2163364365 @default.
- W3191215618 cites W2164233939 @default.
- W3191215618 cites W2173001239 @default.
- W3191215618 cites W2284510982 @default.
- W3191215618 cites W2465617270 @default.
- W3191215618 cites W2558714648 @default.
- W3191215618 cites W2583280440 @default.
- W3191215618 cites W2766676715 @default.
- W3191215618 cites W2796777502 @default.
- W3191215618 cites W3015635259 @default.
- W3191215618 cites W3119867490 @default.
- W3191215618 cites W3134887329 @default.
- W3191215618 cites W3159530603 @default.
- W3191215618 doi "https://doi.org/10.1016/j.humpath.2021.07.013" @default.
- W3191215618 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34371060" @default.
- W3191215618 hasPublicationYear "2021" @default.
- W3191215618 type Work @default.
- W3191215618 sameAs 3191215618 @default.
- W3191215618 citedByCount "4" @default.
- W3191215618 countsByYear W31912156182021 @default.
- W3191215618 countsByYear W31912156182022 @default.
- W3191215618 countsByYear W31912156182023 @default.
- W3191215618 crossrefType "journal-article" @default.
- W3191215618 hasAuthorship W3191215618A5003055755 @default.
- W3191215618 hasAuthorship W3191215618A5018228791 @default.
- W3191215618 hasAuthorship W3191215618A5035371015 @default.
- W3191215618 hasAuthorship W3191215618A5051254921 @default.
- W3191215618 hasAuthorship W3191215618A5057612848 @default.
- W3191215618 hasAuthorship W3191215618A5065237325 @default.
- W3191215618 hasAuthorship W3191215618A5070001516 @default.
- W3191215618 hasAuthorship W3191215618A5083962017 @default.
- W3191215618 hasAuthorship W3191215618A5085659906 @default.
- W3191215618 hasBestOaLocation W31912156182 @default.
- W3191215618 hasConcept C104317684 @default.
- W3191215618 hasConcept C121608353 @default.
- W3191215618 hasConcept C126322002 @default.
- W3191215618 hasConcept C142724271 @default.
- W3191215618 hasConcept C501734568 @default.
- W3191215618 hasConcept C502942594 @default.
- W3191215618 hasConcept C526805850 @default.
- W3191215618 hasConcept C54355233 @default.
- W3191215618 hasConcept C71924100 @default.
- W3191215618 hasConcept C76818968 @default.
- W3191215618 hasConcept C86803240 @default.
- W3191215618 hasConceptScore W3191215618C104317684 @default.
- W3191215618 hasConceptScore W3191215618C121608353 @default.
- W3191215618 hasConceptScore W3191215618C126322002 @default.
- W3191215618 hasConceptScore W3191215618C142724271 @default.
- W3191215618 hasConceptScore W3191215618C501734568 @default.
- W3191215618 hasConceptScore W3191215618C502942594 @default.
- W3191215618 hasConceptScore W3191215618C526805850 @default.
- W3191215618 hasConceptScore W3191215618C54355233 @default.
- W3191215618 hasConceptScore W3191215618C71924100 @default.
- W3191215618 hasConceptScore W3191215618C76818968 @default.
- W3191215618 hasConceptScore W3191215618C86803240 @default.
- W3191215618 hasLocation W31912156181 @default.
- W3191215618 hasLocation W31912156182 @default.
- W3191215618 hasLocation W31912156183 @default.
- W3191215618 hasOpenAccess W3191215618 @default.
- W3191215618 hasPrimaryLocation W31912156181 @default.
- W3191215618 hasRelatedWork W2000479004 @default.
- W3191215618 hasRelatedWork W2139614449 @default.
- W3191215618 hasRelatedWork W2172257311 @default.
- W3191215618 hasRelatedWork W2392730113 @default.
- W3191215618 hasRelatedWork W2409949902 @default.
- W3191215618 hasRelatedWork W2462467799 @default.