Matches in SemOpenAlex for { <https://semopenalex.org/work/W3191234098> ?p ?o ?g. }
- W3191234098 endingPage "3294" @default.
- W3191234098 startingPage "3279" @default.
- W3191234098 abstract "Abstract While photodynamic therapy (PDT) can induce acute inflammation in the irradiated tumor site, a sustained systemic, adaptive immune response is desirable, as it may control the growth of nonirradiated distant disease. Previously, we developed porphyrin lipoprotein (PLP), a ∼20 nm nanoparticle photosensitizer, and observed that it not only efficiently eradicated irradiated primary VX2 buccal carcinomas in rabbits, but also induced regression of nonirradiated metastases in a draining lymph node. We hypothesized that PLP-mediated PDT can induce an abscopal effect and we sought to investigate the immune mechanism underlying such a response in a highly aggressive, dual subcutaneous AE17-OVA+ mesothelioma model in C57BL/6 mice. Four cycles of PLP-mediated PDT was sufficient to delay the growth of a distal, nonirradiated tumor four-fold relative to controls. Serum cytokine analysis revealed high interleukin-6 levels, showing a 30-fold increase relative to phosphate-buffered solution (PBS) treated mice. Flow cytometry revealed an increase in CD4+ T cells and effector memory CD8+ T cells in non-irradiated tumors. Notably, PDT in combination with PD-1 antibody therapy prolonged survival compared to monotherapy and PBS. PLP-mediated PDT shows promise in generating a systemic immune response that can complement other treatments, improving prognoses for patients with metastatic cancers." @default.
- W3191234098 created "2021-08-16" @default.
- W3191234098 creator A5001586221 @default.
- W3191234098 creator A5002026055 @default.
- W3191234098 creator A5003853385 @default.
- W3191234098 creator A5005272472 @default.
- W3191234098 creator A5005274445 @default.
- W3191234098 creator A5026071162 @default.
- W3191234098 creator A5041544898 @default.
- W3191234098 creator A5050029611 @default.
- W3191234098 creator A5055112129 @default.
- W3191234098 creator A5057561295 @default.
- W3191234098 creator A5074698433 @default.
- W3191234098 creator A5075963709 @default.
- W3191234098 creator A5076636443 @default.
- W3191234098 creator A5082975643 @default.
- W3191234098 creator A5087033400 @default.
- W3191234098 date "2021-08-03" @default.
- W3191234098 modified "2023-10-12" @default.
- W3191234098 title "Repeated porphyrin lipoprotein-based photodynamic therapy controls distant disease in mouse mesothelioma via the abscopal effect" @default.
- W3191234098 cites W1910012553 @default.
- W3191234098 cites W2000603985 @default.
- W3191234098 cites W2010241704 @default.
- W3191234098 cites W2025155642 @default.
- W3191234098 cites W2026822060 @default.
- W3191234098 cites W2036802115 @default.
- W3191234098 cites W2058288464 @default.
- W3191234098 cites W2066659514 @default.
- W3191234098 cites W2071163755 @default.
- W3191234098 cites W2073432742 @default.
- W3191234098 cites W2084906892 @default.
- W3191234098 cites W2089966068 @default.
- W3191234098 cites W2139122813 @default.
- W3191234098 cites W2184282455 @default.
- W3191234098 cites W2429541564 @default.
- W3191234098 cites W2515854919 @default.
- W3191234098 cites W2529367234 @default.
- W3191234098 cites W2558284519 @default.
- W3191234098 cites W2603827936 @default.
- W3191234098 cites W2752906572 @default.
- W3191234098 cites W2764028271 @default.
- W3191234098 cites W2766149272 @default.
- W3191234098 cites W2766527333 @default.
- W3191234098 cites W2783708904 @default.
- W3191234098 cites W2791749859 @default.
- W3191234098 cites W2885347656 @default.
- W3191234098 cites W2897926811 @default.
- W3191234098 cites W2898402413 @default.
- W3191234098 cites W2980232636 @default.
- W3191234098 cites W2994237727 @default.
- W3191234098 cites W3009426500 @default.
- W3191234098 cites W3118825661 @default.
- W3191234098 cites W3122627530 @default.
- W3191234098 cites W3136319535 @default.
- W3191234098 cites W3188375976 @default.
- W3191234098 cites W3207665479 @default.
- W3191234098 doi "https://doi.org/10.1515/nanoph-2021-0241" @default.
- W3191234098 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36405502" @default.
- W3191234098 hasPublicationYear "2021" @default.
- W3191234098 type Work @default.
- W3191234098 sameAs 3191234098 @default.
- W3191234098 citedByCount "10" @default.
- W3191234098 countsByYear W31912340982021 @default.
- W3191234098 countsByYear W31912340982022 @default.
- W3191234098 countsByYear W31912340982023 @default.
- W3191234098 crossrefType "journal-article" @default.
- W3191234098 hasAuthorship W3191234098A5001586221 @default.
- W3191234098 hasAuthorship W3191234098A5002026055 @default.
- W3191234098 hasAuthorship W3191234098A5003853385 @default.
- W3191234098 hasAuthorship W3191234098A5005272472 @default.
- W3191234098 hasAuthorship W3191234098A5005274445 @default.
- W3191234098 hasAuthorship W3191234098A5026071162 @default.
- W3191234098 hasAuthorship W3191234098A5041544898 @default.
- W3191234098 hasAuthorship W3191234098A5050029611 @default.
- W3191234098 hasAuthorship W3191234098A5055112129 @default.
- W3191234098 hasAuthorship W3191234098A5057561295 @default.
- W3191234098 hasAuthorship W3191234098A5074698433 @default.
- W3191234098 hasAuthorship W3191234098A5075963709 @default.
- W3191234098 hasAuthorship W3191234098A5076636443 @default.
- W3191234098 hasAuthorship W3191234098A5082975643 @default.
- W3191234098 hasAuthorship W3191234098A5087033400 @default.
- W3191234098 hasBestOaLocation W31912340981 @default.
- W3191234098 hasConcept C142724271 @default.
- W3191234098 hasConcept C167672396 @default.
- W3191234098 hasConcept C178790620 @default.
- W3191234098 hasConcept C185592680 @default.
- W3191234098 hasConcept C203014093 @default.
- W3191234098 hasConcept C2777407522 @default.
- W3191234098 hasConcept C2777701055 @default.
- W3191234098 hasConcept C2778690821 @default.
- W3191234098 hasConcept C2780849966 @default.
- W3191234098 hasConcept C2781274730 @default.
- W3191234098 hasConcept C2781323092 @default.
- W3191234098 hasConcept C2781469039 @default.
- W3191234098 hasConcept C502942594 @default.
- W3191234098 hasConcept C553184892 @default.
- W3191234098 hasConcept C71924100 @default.
- W3191234098 hasConcept C8891405 @default.