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- W3191376815 endingPage "1865" @default.
- W3191376815 startingPage "1855" @default.
- W3191376815 abstract "Pulmonary arterial hypertension (PAH) is a fatal disease of the cardiopulmonary system that lacks curative treatments. The main pathological event in PAH is elevated vascular resistance in the pulmonary circulation, caused by abnormal vasoconstriction and vascular remodelling. Ion channels are key determinants of vascular smooth muscle tone and homeostasis, and four PAH channelopathies (KCNK3, ABCC8, KCNA5, TRPC6) have been identified so far. However, the contribution of ion channels in other forms of PAH, which account for the majority of PAH patients, has been less well characterised. Here we reason that a variety of triggers of PAH (e.g. BMPR2 mutations, hypoxia, anorectic drugs) that impact channel function may contribute to the onset of the disease. We review the molecular mechanisms by which these 'extrinsic' factors converge on ion channels and provoke their dysregulation to promote the development of PAH. Ion channels of the pulmonary vasculature are therefore promising therapeutic targets because of the modulation they provide to both vasomotor tone and proliferation of arterial smooth muscle cells." @default.
- W3191376815 created "2021-08-16" @default.
- W3191376815 creator A5085948404 @default.
- W3191376815 creator A5089871276 @default.
- W3191376815 creator A5067601606 @default.
- W3191376815 date "2021-08-04" @default.
- W3191376815 modified "2023-09-26" @default.
- W3191376815 title "Ion channels as convergence points in the pathology of pulmonary arterial hypertension" @default.
- W3191376815 cites W1508200059 @default.
- W3191376815 cites W1866413456 @default.
- W3191376815 cites W1876419424 @default.
- W3191376815 cites W1940480815 @default.
- W3191376815 cites W1963632940 @default.
- W3191376815 cites W1963782060 @default.
- W3191376815 cites W1965078214 @default.
- W3191376815 cites W1976117941 @default.
- W3191376815 cites W1986081870 @default.
- W3191376815 cites W1999065344 @default.
- W3191376815 cites W1999887461 @default.
- W3191376815 cites W2006343358 @default.
- W3191376815 cites W2015183893 @default.
- W3191376815 cites W2016280101 @default.
- W3191376815 cites W2017342488 @default.
- W3191376815 cites W2018318070 @default.
- W3191376815 cites W2021102672 @default.
- W3191376815 cites W2027265533 @default.
- W3191376815 cites W2030412425 @default.
- W3191376815 cites W2035653659 @default.
- W3191376815 cites W2038353863 @default.
- W3191376815 cites W2040540600 @default.
- W3191376815 cites W2044956310 @default.
- W3191376815 cites W2053940699 @default.
- W3191376815 cites W2058338257 @default.
- W3191376815 cites W2062279213 @default.
- W3191376815 cites W2070002665 @default.
- W3191376815 cites W2070667821 @default.
- W3191376815 cites W2073767174 @default.
- W3191376815 cites W2074695080 @default.
- W3191376815 cites W2081414376 @default.
- W3191376815 cites W2083998789 @default.
- W3191376815 cites W2084925375 @default.
- W3191376815 cites W2100642038 @default.
- W3191376815 cites W2103424889 @default.
- W3191376815 cites W2108810476 @default.
- W3191376815 cites W2111760435 @default.
- W3191376815 cites W2116775624 @default.
- W3191376815 cites W2117597411 @default.
- W3191376815 cites W2123893151 @default.
- W3191376815 cites W2128213692 @default.
- W3191376815 cites W2128697694 @default.
- W3191376815 cites W2133763246 @default.
- W3191376815 cites W2149483660 @default.
- W3191376815 cites W2158364013 @default.
- W3191376815 cites W2161603584 @default.
- W3191376815 cites W2166985476 @default.
- W3191376815 cites W2192323341 @default.
- W3191376815 cites W2271695082 @default.
- W3191376815 cites W2282364919 @default.
- W3191376815 cites W2323357966 @default.
- W3191376815 cites W2333322085 @default.
- W3191376815 cites W2339146964 @default.
- W3191376815 cites W2432064922 @default.
- W3191376815 cites W2511160768 @default.
- W3191376815 cites W2519039755 @default.
- W3191376815 cites W2581388053 @default.
- W3191376815 cites W2586241610 @default.
- W3191376815 cites W2621496307 @default.
- W3191376815 cites W2626699816 @default.
- W3191376815 cites W2684072363 @default.
- W3191376815 cites W2753727447 @default.
- W3191376815 cites W2786757783 @default.
- W3191376815 cites W2789771154 @default.
- W3191376815 cites W2796769914 @default.
- W3191376815 cites W2800579983 @default.
- W3191376815 cites W2883785913 @default.
- W3191376815 cites W2888606868 @default.
- W3191376815 cites W2894677876 @default.
- W3191376815 cites W2894893795 @default.
- W3191376815 cites W2897065794 @default.
- W3191376815 cites W2897723629 @default.
- W3191376815 cites W2900758647 @default.
- W3191376815 cites W2904583838 @default.
- W3191376815 cites W2905290778 @default.
- W3191376815 cites W2911131097 @default.
- W3191376815 cites W2920329607 @default.
- W3191376815 cites W2941209344 @default.
- W3191376815 cites W2953984941 @default.
- W3191376815 cites W2964522868 @default.
- W3191376815 cites W2966687484 @default.
- W3191376815 cites W2968663009 @default.
- W3191376815 cites W2973951274 @default.
- W3191376815 cites W2976172455 @default.
- W3191376815 cites W2981736549 @default.
- W3191376815 cites W2995516686 @default.
- W3191376815 cites W3000962954 @default.
- W3191376815 cites W3005672853 @default.
- W3191376815 cites W3006273690 @default.
- W3191376815 cites W3012017698 @default.