FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3191403432> ?p ?o ?g. }

• W3191403432 abstract "Abstract Background Whether differences in circulating long chain acylcarnitines (LCAC) are seen in heart failure (HF) patients with and without diabetes mellitus (DM), and whether these biomarkers report on exercise capacity and clinical outcomes, remains unknown. The objective of the current study was to use metabolomic profiling to identify biomarkers that report on exercise capacity, clinical outcomes, and differential response to exercise in HF patients with and without DM. Methods Targeted mass spectrometry was used to quantify metabolites in plasma from participants in the heart failure: a controlled trial investigating outcomes of exercise training (HF-ACTION) trial. Principal components analysis was used to identify 12 uncorrelated factors. The association between metabolite factors, diabetes status, exercise capacity, and time to the primary clinical outcome of all-cause mortality or all-cause hospitalization was assessed. Results A total of 664 participants were included: 359 (54%) with DM. LCAC factor levels were associated with baseline exercise capacity as measured by peak oxygen consumption (beta 0.86, p = 2 × 10 −7 , and were differentially associated in participants with and without DM (beta 1.58, p = 8 × 10 −8 vs. 0.67, p = 9 × 10 −4 , respectively; p value for interaction = 0.012). LCAC levels changed to a lesser extent in participants with DM after exercise (mean ∆ 0.09, p = 0.24) than in those without DM (mean ∆ 0.16, p = 0.08). In univariate and multivariate modeling, LCAC factor levels were associated with time to the primary outcome (multivariate HR 0.80, p = 2.74 × 10 −8 ), and were more strongly linked to outcomes in diabetic participants (HR 0.64, p = 3.21 × 10 −9 v. HR 0.90, p = 0.104, p value for interaction = 0.001). When analysis was performed at the level of individual metabolites, C16, C16:1, C18, and C18:1 had the greatest associations with both exercise capacity and outcomes, with higher levels associated with worse outcomes. Similar associations with time to the primary clinical outcome were not found in a control group of patients without HF from the CATHeterization GENetics (CATHGEN) study. Conclusions LCAC biomarkers are associated with exercise status and clinical outcomes differentially in HF patients with and without DM. Impaired fatty acid substrate utilization and mitochondrial dysfunction both at the level of the skeletal muscle and the myocardium may explain the decreased exercise capacity, attenuated response to exercise training, and poor clinical outcomes seen in patients with HF and DM. Trial Registration clinicaltrials.gov Identifier: NCT00047437." @default.
• W3191403432 created "2021-08-16" @default.
• W3191403432 creator A5015595507 @default.
• W3191403432 creator A5017226394 @default.
• W3191403432 creator A5021832589 @default.
• W3191403432 creator A5022076272 @default.
• W3191403432 creator A5022951863 @default.
• W3191403432 creator A5029499930 @default.
• W3191403432 creator A5044894867 @default.
• W3191403432 creator A5055488258 @default.
• W3191403432 creator A5055822075 @default.
• W3191403432 creator A5062992566 @default.
• W3191403432 creator A5083259323 @default.
• W3191403432 date "2021-08-03" @default.
• W3191403432 modified "2023-10-02" @default.
• W3191403432 title "Circulating long chain acylcarnitines and outcomes in diabetic heart failure: an HF-ACTION clinical trial substudy" @default.
• W3191403432 cites W157502360 @default.
• W3191403432 cites W164205712 @default.
• W3191403432 cites W1890886324 @default.
• W3191403432 cites W1968853872 @default.
• W3191403432 cites W1974438296 @default.
• W3191403432 cites W1999736924 @default.
• W3191403432 cites W2001466001 @default.
• W3191403432 cites W2028621708 @default.
• W3191403432 cites W2064612269 @default.
• W3191403432 cites W2108049767 @default.
• W3191403432 cites W2118634943 @default.
• W3191403432 cites W2135378280 @default.
• W3191403432 cites W2137689126 @default.
• W3191403432 cites W2153819921 @default.
• W3191403432 cites W2158592541 @default.
• W3191403432 cites W2193380125 @default.
• W3191403432 cites W2278098643 @default.
• W3191403432 cites W2484301708 @default.
• W3191403432 cites W2523406925 @default.
• W3191403432 cites W2735723295 @default.
• W3191403432 cites W2765938685 @default.
• W3191403432 cites W2796174912 @default.
• W3191403432 cites W2883963712 @default.
• W3191403432 cites W2908520130 @default.
• W3191403432 cites W2913705661 @default.
• W3191403432 cites W3006949946 @default.
• W3191403432 cites W3092932642 @default.
• W3191403432 doi "https://doi.org/10.1186/s12933-021-01353-z" @default.
• W3191403432 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8336082" @default.
• W3191403432 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34344360" @default.
• W3191403432 hasPublicationYear "2021" @default.
• W3191403432 type Work @default.
• W3191403432 sameAs 3191403432 @default.
• W3191403432 citedByCount "6" @default.
• W3191403432 countsByYear W31914034322022 @default.
• W3191403432 countsByYear W31914034322023 @default.
• W3191403432 crossrefType "journal-article" @default.
• W3191403432 hasAuthorship W3191403432A5015595507 @default.
• W3191403432 hasAuthorship W3191403432A5017226394 @default.
• W3191403432 hasAuthorship W3191403432A5021832589 @default.
• W3191403432 hasAuthorship W3191403432A5022076272 @default.
• W3191403432 hasAuthorship W3191403432A5022951863 @default.
• W3191403432 hasAuthorship W3191403432A5029499930 @default.
• W3191403432 hasAuthorship W3191403432A5044894867 @default.
• W3191403432 hasAuthorship W3191403432A5055488258 @default.
• W3191403432 hasAuthorship W3191403432A5055822075 @default.
• W3191403432 hasAuthorship W3191403432A5062992566 @default.
• W3191403432 hasAuthorship W3191403432A5083259323 @default.
• W3191403432 hasBestOaLocation W31914034321 @default.
• W3191403432 hasConcept C126322002 @default.
• W3191403432 hasConcept C134018914 @default.
• W3191403432 hasConcept C164705383 @default.
• W3191403432 hasConcept C2778198053 @default.
• W3191403432 hasConcept C2780221984 @default.
• W3191403432 hasConcept C38180746 @default.
• W3191403432 hasConcept C555175668 @default.
• W3191403432 hasConcept C555293320 @default.
• W3191403432 hasConcept C71924100 @default.
• W3191403432 hasConcept C77350462 @default.
• W3191403432 hasConceptScore W3191403432C126322002 @default.
• W3191403432 hasConceptScore W3191403432C134018914 @default.
• W3191403432 hasConceptScore W3191403432C164705383 @default.
• W3191403432 hasConceptScore W3191403432C2778198053 @default.
• W3191403432 hasConceptScore W3191403432C2780221984 @default.
• W3191403432 hasConceptScore W3191403432C38180746 @default.
• W3191403432 hasConceptScore W3191403432C555175668 @default.
• W3191403432 hasConceptScore W3191403432C555293320 @default.
• W3191403432 hasConceptScore W3191403432C71924100 @default.
• W3191403432 hasConceptScore W3191403432C77350462 @default.
• W3191403432 hasFunder F4320306230 @default.
• W3191403432 hasIssue "1" @default.
• W3191403432 hasLocation W31914034321 @default.
• W3191403432 hasLocation W31914034322 @default.
• W3191403432 hasLocation W31914034323 @default.
• W3191403432 hasOpenAccess W3191403432 @default.
• W3191403432 hasPrimaryLocation W31914034321 @default.
• W3191403432 hasRelatedWork W1966504330 @default.
• W3191403432 hasRelatedWork W1979139803 @default.
• W3191403432 hasRelatedWork W2004945833 @default.
• W3191403432 hasRelatedWork W2030889776 @default.
• W3191403432 hasRelatedWork W2037631372 @default.
• W3191403432 hasRelatedWork W2040058909 @default.
• W3191403432 hasRelatedWork W2132898409 @default.
• W3191403432 hasRelatedWork W2161391746 @default.

• next