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- W3191420156 abstract "Characterization of host-microbiota interactions at mucosal surfaces is essential for understanding the role of microbial dysbiosis in the pathogenesis of immune-mediated diseases. However, identifying the microbe-specific mucosal immune response in humans has challenges in distinguishing microorganisms that directly interact with the mucosa and capturing local host responses to them. Here, we performed a paralleled analysis on host gene expression and microbiota activity profiles of 436 conjunctival metatranscriptomes from 109 monozygotic twin pairs. Our within-twin-pair analysis revealed associations between the activity of microbial species and immune cells, cytokines, and human leukocyte antigens, while excluding the influence of host genetics and the environment . We further identified an association of Gordonia bronchialis with ocular graft-versus-host disease (GVHD) by surveying conjunctival metagenomes from 124 individuals and analyzed the putative role of this species in GVHD, demonstrating potential implications of the microbial species-specific human mucosal responses in investigating the etiology of immune-mediated diseases." @default.
- W3191420156 created "2021-08-16" @default.
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- W3191420156 date "2021-01-01" @default.
- W3191420156 modified "2023-09-26" @default.
- W3191420156 title "The Landscape of Host-Microbiota Interactions at the Ocular Mucosa" @default.
- W3191420156 doi "https://doi.org/10.2139/ssrn.3895932" @default.
- W3191420156 hasPublicationYear "2021" @default.
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