Matches in SemOpenAlex for { <https://semopenalex.org/work/W3191508265> ?p ?o ?g. }
- W3191508265 endingPage "93" @default.
- W3191508265 startingPage "87" @default.
- W3191508265 abstract "Despite the dramatic underrepresentation of non-European populations in human genetics studies, researchers continue to exclude participants of non-European ancestry, as well as variants rare in European populations, even when these data are available. This practice perpetuates existing research disparities and can lead to important and large effect size associations being missed. Here, we conducted genome-wide association studies (GWAS) of 31 serum and urine biomarker quantitative traits in African (n = 9354), East Asian (n = 2559), and South Asian (n = 9823) ancestry UK Biobank (UKBB) participants. We adjusted for all known GWAS catalog variants for each trait, as well as novel signals identified in a recent European ancestry-focused analysis of UKBB participants. We identify 7 novel signals in African ancestry and 2 novel signals in South Asian ancestry participants (p < 1.61E−10). Many of these signals are highly plausible, including a cis pQTL for the gene encoding gamma-glutamyl transferase and PIEZO1 and G6PD variants with impacts on HbA1c through likely erythrocytic mechanisms. This work illustrates the importance of using the genetic data we already have in diverse populations, with novel discoveries possible in even modest sample sizes." @default.
- W3191508265 created "2021-08-16" @default.
- W3191508265 creator A5000878758 @default.
- W3191508265 creator A5003856334 @default.
- W3191508265 creator A5004946791 @default.
- W3191508265 creator A5006058315 @default.
- W3191508265 creator A5008481316 @default.
- W3191508265 creator A5016826447 @default.
- W3191508265 creator A5031945784 @default.
- W3191508265 creator A5032020402 @default.
- W3191508265 creator A5036388273 @default.
- W3191508265 creator A5039356214 @default.
- W3191508265 creator A5042360941 @default.
- W3191508265 creator A5043242150 @default.
- W3191508265 creator A5043373639 @default.
- W3191508265 creator A5054683932 @default.
- W3191508265 creator A5057616349 @default.
- W3191508265 creator A5061806340 @default.
- W3191508265 creator A5062296084 @default.
- W3191508265 creator A5076419751 @default.
- W3191508265 creator A5079126851 @default.
- W3191508265 date "2021-08-11" @default.
- W3191508265 modified "2023-10-16" @default.
- W3191508265 title "Analyses of biomarker traits in diverse UK biobank participants identify associations missed by European-centric analysis strategies" @default.
- W3191508265 cites W1966492464 @default.
- W3191508265 cites W2004589830 @default.
- W3191508265 cites W2004878818 @default.
- W3191508265 cites W2006776184 @default.
- W3191508265 cites W2024365856 @default.
- W3191508265 cites W2029920884 @default.
- W3191508265 cites W2035728929 @default.
- W3191508265 cites W2141198361 @default.
- W3191508265 cites W2151292542 @default.
- W3191508265 cites W2153118028 @default.
- W3191508265 cites W2163013660 @default.
- W3191508265 cites W2290627980 @default.
- W3191508265 cites W2290720752 @default.
- W3191508265 cites W2340513358 @default.
- W3191508265 cites W2465575411 @default.
- W3191508265 cites W2587727230 @default.
- W3191508265 cites W2588964971 @default.
- W3191508265 cites W2592492263 @default.
- W3191508265 cites W2616325230 @default.
- W3191508265 cites W2755166087 @default.
- W3191508265 cites W2756084911 @default.
- W3191508265 cites W2771559482 @default.
- W3191508265 cites W2792625647 @default.
- W3191508265 cites W2889800760 @default.
- W3191508265 cites W2891631301 @default.
- W3191508265 cites W2895486342 @default.
- W3191508265 cites W2910093806 @default.
- W3191508265 cites W2932671560 @default.
- W3191508265 cites W2946868714 @default.
- W3191508265 cites W2948231221 @default.
- W3191508265 cites W2952013316 @default.
- W3191508265 cites W2955214642 @default.
- W3191508265 cites W2961813371 @default.
- W3191508265 cites W2965553447 @default.
- W3191508265 cites W2975448719 @default.
- W3191508265 cites W2980812422 @default.
- W3191508265 cites W2981754575 @default.
- W3191508265 cites W2996024184 @default.
- W3191508265 cites W3013967575 @default.
- W3191508265 cites W3019421736 @default.
- W3191508265 cites W3035607564 @default.
- W3191508265 cites W3082575318 @default.
- W3191508265 cites W3121239749 @default.
- W3191508265 doi "https://doi.org/10.1038/s10038-021-00968-0" @default.
- W3191508265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34376796" @default.
- W3191508265 hasPublicationYear "2021" @default.
- W3191508265 type Work @default.
- W3191508265 sameAs 3191508265 @default.
- W3191508265 citedByCount "20" @default.
- W3191508265 countsByYear W31915082652021 @default.
- W3191508265 countsByYear W31915082652022 @default.
- W3191508265 countsByYear W31915082652023 @default.
- W3191508265 crossrefType "journal-article" @default.
- W3191508265 hasAuthorship W3191508265A5000878758 @default.
- W3191508265 hasAuthorship W3191508265A5003856334 @default.
- W3191508265 hasAuthorship W3191508265A5004946791 @default.
- W3191508265 hasAuthorship W3191508265A5006058315 @default.
- W3191508265 hasAuthorship W3191508265A5008481316 @default.
- W3191508265 hasAuthorship W3191508265A5016826447 @default.
- W3191508265 hasAuthorship W3191508265A5031945784 @default.
- W3191508265 hasAuthorship W3191508265A5032020402 @default.
- W3191508265 hasAuthorship W3191508265A5036388273 @default.
- W3191508265 hasAuthorship W3191508265A5039356214 @default.
- W3191508265 hasAuthorship W3191508265A5042360941 @default.
- W3191508265 hasAuthorship W3191508265A5043242150 @default.
- W3191508265 hasAuthorship W3191508265A5043373639 @default.
- W3191508265 hasAuthorship W3191508265A5054683932 @default.
- W3191508265 hasAuthorship W3191508265A5057616349 @default.
- W3191508265 hasAuthorship W3191508265A5061806340 @default.
- W3191508265 hasAuthorship W3191508265A5062296084 @default.
- W3191508265 hasAuthorship W3191508265A5076419751 @default.
- W3191508265 hasAuthorship W3191508265A5079126851 @default.
- W3191508265 hasBestOaLocation W31915082652 @default.
- W3191508265 hasConcept C104317684 @default.